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Syp Gene Detail
Summary
  • Symbol
    Syp
  • Name
    synaptophysin
  • Synonyms
    A230093K24Rik, p38, Syn, Syp I
  • Feature Type
    protein coding gene
  • IDs
    MGI:98467
    NCBI Gene: 20977
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7504819-7519495 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.44 cM, cytoband A-D
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98467
 protein coding gene ChrX:7504710-7519495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035515
 protein coding gene ChrX:2251412-2266725 (+)
A/J MGP_AJ_G0035493
 protein coding gene ChrX:2211985-2228064 (+)
AKR/J MGP_AKRJ_G0035426
 protein coding gene ChrX:2313321-2329987 (+)
BALB/cJ MGP_BALBcJ_G0035489
 protein coding gene ChrX:2230983-2246302 (+)
C3H/HeJ MGP_C3HHeJ_G0035197
 protein coding gene ChrX:2285371-2300049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036013
 protein coding gene ChrX:2328614-2343300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032888
 protein coding gene ChrX:1780007-1794574 (+)
CAST/EiJ MGP_CASTEiJ_G0034497
 protein coding gene ChrX:2185319-2200904 (+)
CBA/J MGP_CBAJ_G0035167
 protein coding gene ChrX:2441707-2460736 (+)
DBA/2J MGP_DBA2J_G0035324
 protein coding gene ChrX:2232988-2247681 (+)
FVB/NJ MGP_FVBNJ_G0035271
 protein coding gene ChrX:2196928-2211515 (+)
LP/J MGP_LPJ_G0035401
 protein coding gene ChrX:2252795-2267495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035310
 protein coding gene ChrX:2406165-2423238 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036031
 protein coding gene ChrX:2234384-2249063 (+)
PWK/PhJ MGP_PWKPhJ_G0034199
 protein coding gene ChrX:2165518-2180740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034036
 protein coding gene ChrX:2204691-2219255 (+)
WSB/EiJ MGP_WSBEiJ_G0034620
 protein coding gene ChrX:2237069-2254581 (+)



Homology
more
  • Human Ortholog
    SYP, synaptophysin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYP, synaptophysin
  • Synonyms
    MRX96, MRXSYP, XLID96
  • Links
    NCBI Gene ID: 6855
    neXtProt AC: NX_P08247
    UniProt: P08247

  • Chr Location
    Xp11.23; chrX:49187815-49200218 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SYP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for either one of two independently generated knock-out mutations are viable and fertile and display normal central nervous system morphology and synaptic transmission with no detectable changes in synaptic plasticity or neurotransmitter release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1066
  • Tissues
    137
  • cDNA Data
    110
  • Literature Summary
    304
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20977 NCBI Gene Model | MGI Sequence Detail 14677 C57BL/6J ±  kb
    transcript NM_009305 RefSeq | MGI Sequence Detail 2482 ZRU/MplStud  
    polypeptide Q62277 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 128
      Genomic 12
      cDNA 113
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14690, MGI:2147923, MGI:2441790
    References
    more
    • Summaries
      All 413
      Developmental Gene Expression 304
      Gene Ontology 45
      Phenotypes 25
    • Earliest
      J:10700 Ozcelik T, et al., Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am J Hum Genet. 1990 Sep;47(3):551-61
    • Latest
      J:346070 Godoy-Corchuelo JM, et al., TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43. Neurobiol Dis. 2024 Feb 15;193:106437
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory