Sos2 MGI Mouse Gene Detail - MGI:98355 - SOS Ras/Rho guanine nucleotide exchange factor 2

Symbol

Sos2
Name

SOS Ras/Rho guanine nucleotide exchange factor 2

Feature Type

protein coding gene
IDs

MGI:98355
NCBI Gene: 20663
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:69630536-69728626 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 28.93 cM, cytoband C3-D
Mapping Data

9 experiments

SNPs within 2kb

2277 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98355	protein coding gene	Chr12:69630535-69728626 (-)
129S1/SvImJ	ENSMUSG00200030871	protein coding gene	Chr12:61542521-61643303 (-)
A/J	ENSMUSG00195012879	protein coding gene	Chr12:64229322-64333177 (-)
AKR/J	ENSMUSG00220014513	protein coding gene	Chr12:62022534-62133750 (-)
BALB/cJ	ENSMUSG00180032335	protein coding gene	Chr12:63228401-63332242 (-)
C3H/HeJ	ENSMUSG00175025571	protein coding gene	Chr12:66322814-66426657 (-)
C57BL/6NJ	ENSMUSG00215016301	protein coding gene	Chr12:62613876-62718116 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017808	protein coding gene	Chr12:64239066-64335197 (-)
CAST/EiJ	ENSTCUGG00005054272	protein coding gene	Chr12:62572560-62670566 (-)
CBA/J	ENSMUSG00210029485	protein coding gene	Chr12:62792836-62896687 (-)
DBA/2J	ENSMUSG00185004272	protein coding gene	Chr12:64692413-64795806 (-)
FVB/NJ	ENSMUSG00205016993	protein coding gene	Chr12:62415541-62538127 (-)
JF1/MsJ	ENSUMUGG00000058408	protein coding gene	Chr12:68657470-68757439 (-)
LP/J	ENSMUSG00230015489	protein coding gene	Chr12:71655036-71761476 (-)
NOD/ShiLtJ	ENSMUSG00190010672	protein coding gene	Chr12:61843926-61949931 (-)
NZO/HlLtJ	ENSMUSG00225037521	protein coding gene	Chr12:73744682-73845070 (-)
PWK/PhJ	ENSLUMGG00010053878	protein coding gene	Chr12:62742931-62838003 (-)
SPRET/EiJ	ENSMSPG00010024811	protein coding gene	Chr12:64425515-64515884 (-)
WSB/EiJ	ENSIUOG00005011634	protein coding gene	Chr12:62483115-62583898 (-)

Human Ortholog

SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2
Synonyms

NS9, SOS-2
Links

HGNC:11188

NCBI Gene ID: 6655

UniProt: Q07890
Chr Location

14q21.3; chr14:50117130-50231906 (-) GRCh38

MGI Vertebrate Homology

Sos2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SOS2
Gene Tree

Sos2

Diseases

1 with human SOS2 associations

				Human Disease	Mouse Models
				Noonan syndrome 9 IDs Noonan syndrome 9 DOID:0060587 ICD10CM:Q87.1 OMIM:616559

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Sos2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available

Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal embryonic and adult histopathology.

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All GO Annotations

25
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

622
Tissues

25
cDNA Data

66
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SOS2

Xenbase sos2

ZFIN sos2

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS59573.1

Ensembl

ENSMUSG00000034801 (Evidence)
NCBI Gene

20663

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034801	Ensembl Gene Model \| MGI Sequence Detail	98091	C57BL/6J	± kb
transcript	ENSMUST00000183277	Ensembl \| MGI Sequence Detail	4512	Not Applicable
polypeptide	ENSMUSP00000138793	Ensembl \| MGI Sequence Detail	1333	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015414 son of sevenless homolog 2

(term hierarchy)
PDB

1GBR
InterPro Domains

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR009072 Histone-fold

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR019804 Ras guanine-nucleotide exchange factor, conserved site

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR008937 Ras-like guanine nucleotide exchange factor

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal

IPR055251 SOS1/NGEF-like, PH domain

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All nucleic 67

Genomic 1

cDNA 66

Antibodies 1

Microarray probesets 3

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MGD-MRK-14490

Summaries

All 59

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 16
Earliest

J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
Latest

J:372383 Baltanas FC, et al., SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS(G12D) inhibitor in KRAS LUAD. Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2422943122

TSS for Sos2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116520	Chr12:69730472-69730485 (-)	-1,853 bp
Tssr116519	Chr12:69729017-69729032 (-)	-399 bp
Tssr116518	Chr12:69728957-69729000 (-)	-353 bp
Tssr116517	Chr12:69728912-69728956 (-)	-308 bp
Tssr116516	Chr12:69728569-69728643 (-)	20 bp
Tssr116515	Chr12:69654081-69654090 (-)	74,540 bp
Tssr116514	Chr12:69643593-69643596 (-)	85,031 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24