Snrnp70 MGI Mouse Gene Detail - MGI:98341 - small nuclear ribonucleoprotein 70 (U1)

Symbol

Snrnp70
Name

small nuclear ribonucleoprotein 70 (U1)
Synonyms

2700022N21Rik, 3200002N22Rik, Rnulp70, Srnp70, U1-70

Feature Type

protein coding gene
IDs

MGI:98341
NCBI Gene: 20637
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:45025877-45045166 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.28 cM
Mapping Data

4 experiments

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98341	protein coding gene	Chr7:45025877-45045177 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032217	protein coding gene	Chr7:45625974-45645156 (-)
A/J	MGP_AJ_G0032196	protein coding gene	Chr7:44762156-44781237 (-)
AKR/J	MGP_AKRJ_G0032132	protein coding gene	Chr7:45991664-46010646 (-)
BALB/cJ	MGP_BALBcJ_G0032208	protein coding gene	Chr7:44751491-44770760 (-)
C3H/HeJ	MGP_C3HHeJ_G0031924	protein coding gene	Chr7:46481979-46501128 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032700	protein coding gene	Chr7:47895531-47917749 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029714	protein coding gene	Chr7:47312546-47333796 (-)
CAST/EiJ	MGP_CASTEiJ_G0031252	protein coding gene	Chr7:37886930-37910582 (-)
CBA/J	MGP_CBAJ_G0031888	protein coding gene	Chr7:49481036-49500101 (-)
DBA/2J	MGP_DBA2J_G0032046	protein coding gene	Chr7:44425640-44445069 (-)
FVB/NJ	MGP_FVBNJ_G0031997	protein coding gene	Chr7:44204444-44226483 (-)
LP/J	MGP_LPJ_G0032124	protein coding gene	Chr7:46330494-46349813 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032034	protein coding gene	Chr7:48179666-48200963 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032716	protein coding gene	Chr7:45210033-45230897 (-)
PWK/PhJ	MGP_PWKPhJ_G0030975	protein coding gene	Chr7:37798315-37820539 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030812	protein coding gene	Chr7:33217984-33245075 (-)
WSB/EiJ	MGP_WSBEiJ_G0031369	protein coding gene	Chr7:45704913-45724076 (-)

Human Ortholog

SNRNP70, small nuclear ribonucleoprotein U1 subunit 70

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNRNP70, small nuclear ribonucleoprotein U1 subunit 70
Synonyms

RNPU1Z, RPU1, Snp1, SNRP70, U170K, U1-70K, U1AP, U1RNP
Links

HGNC:11150

NCBI Gene ID: 6625

neXtProt AC: NX_P08621

UniProt: P08621
Chr Location

19q13.33; chr19:49085419-49108605 (+) GRCh38

MGI Vertebrate Homology

Snrnp70 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNRNP70
Gene Tree

Snrnp70

Diseases

2 with human SNRNP70 associations

				Human Disease	Mouse Models
				disease of mental health IDs disease of mental health DOID:150 ICD10CM:F99 MESH:D001523 NCI:C2893 UMLS_CUI:C0004936
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Endonuclease-mediated

2
Gene trapped

57
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

60
cDNA Data

170
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snrnp70

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All Sequences

101
RefSeq

14
UniProt

12
CCDS

CCDS21240.1

Ensembl

ENSMUSG00000063511 (Evidence)
NCBI Gene

20637

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063511	Ensembl Gene Model \| MGI Sequence Detail	19290	C57BL/6J	± kb
transcript	ENSMUST00000074575	Ensembl \| MGI Sequence Detail	1735	Not Applicable
polypeptide	ENSMUSP00000074160	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000015338 U1 small nuclear ribonucleoprotein 70 kDa

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034143 snRNP70, RNA recognition motif

IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal

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All nucleic 177

Genomic 2

cDNA 173

Primer pair 2

Microarray probesets 5

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MGD-MRK-14003, MGD-MRK-14471, MGD-MRK-14602, MGI:1913569, MGI:1919842, MGI:2141914, MGI:2142381

Summaries

All 55

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 11
Earliest

J:23362 Query CC, et al., A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. Cell. 1987 Oct 23;51(2):211-20
Latest

J:326362 Feng S, et al., hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells. Nat Commun. 2022 Jun 23;13(1):3588

TSS for Snrnp70:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72382	Chr7:45045096-45045143 (-)	46 bp
Tssr72381	Chr7:45044639-45044653 (-)	520 bp
Tssr72380	Chr7:45044606-45044627 (-)	549 bp
Tssr72379	Chr7:45036183-45036187 (-)	8,981 bp
Tssr72378	Chr7:45035222-45035226 (-)	9,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23