Sstr1 MGI Mouse Gene Detail - MGI:98327

Symbol

Sstr1
Name

somatostatin receptor 1
Synonyms

Smstr-1, Smstr1, sst1

Feature Type

protein coding gene
IDs

MGI:98327
NCBI Gene: 20605
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:58258558-58260673 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 25.61 cM
Mapping Data

3 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98327	protein coding gene	Chr12:58258524-58262822 (+)
129S1/SvImJ	ENSMUSG00200028721	protein coding gene	Chr12:50150840-50153508 (+)
A/J	ENSMUSG00195001598	protein coding gene	Chr12:52754132-52756802 (+)
AKR/J	ENSMUSG00220015594	protein coding gene	Chr12:50821219-50823892 (+)
BALB/cJ	ENSMUSG00180007062	protein coding gene	Chr12:51768406-51771076 (+)
C3H/HeJ	ENSMUSG00175015822	protein coding gene	Chr12:54809399-54812069 (+)
C57BL/6NJ	ENSMUSG00215007028	protein coding gene	Chr12:51105209-51107883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017774	protein coding gene	Chr12:53709234-53711974 (+)
CAST/EiJ	ENSTCUG00005012330	protein coding gene	Chr12:51200518-51203191 (+)
CBA/J	ENSMUSG00210014140	protein coding gene	Chr12:51283665-51286335 (+)
DBA/2J	ENSMUSG00185001102	protein coding gene	Chr12:53228914-53231584 (+)
FVB/NJ	ENSMUSG00205005592	protein coding gene	Chr12:51073014-51075685 (+)
JF1/MsJ	ENSUMUG00000006008	protein coding gene	Chr12:57299050-57301736 (+)
LP/J	ENSMUSG00230015375	protein coding gene	Chr12:60256394-60259063 (+)
NOD/ShiLtJ	ENSMUSG00190015375	protein coding gene	Chr12:50277305-50279975 (+)
NZO/HlLtJ	ENSMUSG00225029612	protein coding gene	Chr12:62401241-62403910 (+)
PWK/PhJ	ENSLUMG00010002394	protein coding gene	Chr12:51352874-51355556 (+)
SPRET/EiJ	ENSMSPG00010010904	protein coding gene	Chr12:52842182-52843829 (+)
WSB/EiJ	ENSIUOG00005000923	protein coding gene	Chr12:51129475-51132147 (+)

Human Ortholog

SSTR1, somatostatin receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSTR1, somatostatin receptor 1
Synonyms

SRIF-2, SS-1-R, SS1-R, SS1R, SST1
Links

HGNC:11330

NCBI Gene ID: 6751

UniProt: P30872
Chr Location

14q21.1; chr14:38207904-38213067 (+) GRCh38

MGI Vertebrate Homology

Sstr1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SSTR1
Gene Tree

Sstr1

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Sstr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal eye electrophysiology. Mice homozygous for a second targeted mutation display hypoactivity.

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All GO Annotations

31
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

928
Tissues

119
cDNA Data

6
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sstr1

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS36456.1

Ensembl

ENSMUSG00000035431 (Evidence)
NCBI Gene

20605

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035431	Ensembl Gene Model \| MGI Sequence Detail	2116	C57BL/6J	± kb
transcript	ENSMUST00000110671	Ensembl \| MGI Sequence Detail	1752	Not Applicable
polypeptide	ENSMUSP00000106299	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001668 somatostatin receptor type 1

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001116 Somatostatin receptor 1

IPR000586 Somatostatin receptor family
GlyGen

P30873 3 sites, 1 N-linked glycan (1 site)

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All nucleic 18

Genomic 4

cDNA 6

Primer pair 7

Other 1

Antibodies 2

Microarray probesets 3

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MGD-MRK-14454, MGD-MRK-14457

Summaries

All 76

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 27
Earliest

J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sstr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113534	Chr12:58259056-58259072 (+)	506 bp
Tssr113535	Chr12:58259077-58259095 (+)	528 bp
Tssr113536	Chr12:58259212-58259229 (+)	663 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24