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Saa4 Gene Detail
Summary
  • Symbol
    Saa4
  • Name
    serum amyloid A 4
  • Synonyms
    Saa-4, Saa-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:98224
    NCBI Gene: 20211
  • Member of
    Saa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46377422-46382027 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.53 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98224
 protein coding gene Chr7:46377416-46382027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032269
 protein coding gene Chr7:47119260-47123669 (-)
A/J MGP_AJ_G0032248
 protein coding gene Chr7:46148480-46152893 (-)
AKR/J MGP_AKRJ_G0032184
 protein coding gene Chr7:47435253-47439648 (-)
BALB/cJ MGP_BALBcJ_G0032260
 protein coding gene Chr7:46147875-46152401 (-)
C3H/HeJ MGP_C3HHeJ_G0031975
 protein coding gene Chr7:47935274-47939683 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032752
 protein coding gene Chr7:49390881-49395278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029766
 protein coding gene Chr7:48688901-48693655 (-)
CAST/EiJ MGP_CASTEiJ_G0031303
 protein coding gene Chr7:39378688-39383143 (-)
CBA/J MGP_CBAJ_G0031940
 protein coding gene Chr7:51050921-51055336 (-)
DBA/2J MGP_DBA2J_G0032097
 protein coding gene Chr7:45828654-45833059 (-)
FVB/NJ MGP_FVBNJ_G0032049
 protein coding gene Chr7:45625224-45629625 (-)
LP/J MGP_LPJ_G0032176
 protein coding gene Chr7:47813625-47818116 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032086
 protein coding gene Chr7:49650635-49655046 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032767
 protein coding gene Chr7:46655851-46660248 (-)
PWK/PhJ MGP_PWKPhJ_G0031026
 protein coding gene Chr7:39206439-39210895 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030864
 protein coding gene Chr7:34678791-34683232 (-)
WSB/EiJ MGP_WSBEiJ_G0031421
 protein coding gene Chr7:47160521-47164950 (-)



Homology
more
  • Human Ortholog
    SAA4, serum amyloid A4, constitutive
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAA4, serum amyloid A4, constitutive
  • Synonyms
    C-SAA, CSAA
  • Links
    NCBI Gene ID: 6291
    UniProt: P35542

  • Chr Location
    11p15.1; chr11:18231355-18236802 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    10
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040017 Ensembl Gene Model | MGI Sequence Detail 4606 C57BL/6J ±  kb
transcript ENSMUST00000006952 Ensembl | MGI Sequence Detail 2094 Not Applicable  
polypeptide ENSMUSP00000006952 Ensembl | MGI Sequence Detail 130 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000096 Serum amyloid A protein
    IPR052464 Synovial Proliferation Regulator
Molecular
Reagents
less
  • All nucleic 22
    Genomic 5
    cDNA 12
    Other 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14276, MGD-MRK-14281
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:8180 Stearman RS, et al., The sequence and structure of a new serum amyloid A gene. Nucleic Acids Res. 1986 Jan 24;14(2):797-809
  • Latest
    J:364459 Cimini M, et al., Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction. Cell Rep. 2025 Mar 25;44(3):115408
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory