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Saa3 Gene Detail
Summary
  • Symbol
    Saa3
  • Name
    serum amyloid A 3
  • Synonyms
    l7R3, Saa-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98223
    NCBI Gene: 20210
  • Member of
    Saa cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46361422-46365100 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.51 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98223
 protein coding gene Chr7:46361422-46365124 (-)
129S1/SvImJ ENSMUSG00200028536
 protein coding gene Chr7:33979181-33982883 (-)
A/J ENSMUSG00195036739
 protein coding gene Chr7:37995526-37999230 (-)
AKR/J ENSMUSG00220007707
 protein coding gene Chr7:32290902-32294600 (-)
BALB/cJ ENSMUSG00180035074
 protein coding gene Chr7:34870922-34874622 (-)
C3H/HeJ ENSMUSG00175028883
 protein coding gene Chr7:35415107-35418811 (-)
C57BL/6NJ ENSMUSG00215041412
 protein coding gene Chr7:34654578-34658280 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029765
 protein coding gene Chr7:48673623-48677084 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210045657
 protein coding gene Chr7:35765498-35769200 (-)
DBA/2J ENSMUSG00185046517
 protein coding gene Chr7:39661940-39665644 (-)
FVB/NJ ENSMUSG00205045337
 protein coding gene Chr7:35310073-35313777 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230049793
 protein coding gene Chr7:45086225-45089919 (-)
NOD/ShiLtJ ENSMUSG00190040337
 protein coding gene Chr7:35637738-35641440 (-)
NZO/HlLtJ ENSMUSG00225017124
 protein coding gene Chr7:43289489-43293191 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010039684
 protein coding gene Chr7:34389124-34392760 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SAA1, serum amyloid A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAA1, serum amyloid A1
  • Synonyms
    PIG4, SAA, TP53I4
  • Links
    NCBI Gene ID: 6288
    UniProt: P0DJI8

  • Chr Location
    11p15.1; chr11:18266260-18269977 (+)  GRCh38
  • Human Ortholog
    SAA2, serum amyloid A2
  • Synonyms
    SAA
  • Links
    NCBI Gene ID: 6289
    UniProt: P0DJI9

  • Chr Location
    11p15.1; chr11:18238236-18248668 (-)  GRCh38
  • Human Ortholog
    SAA3P, serum amyloid A3, pseudogene
  • Synonyms
    SAA3
  • Links
    NCBI Gene ID: 6290

  • Chr Location
    11p15.1; chr11:18112472-18116132 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Two chemically induced mutations result in prenatal lethality in homozygous mice. Mice homozygous for a knock-out allele exhibit reduced susceptibility to diet-induced obesity with improved lipid metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    19
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20210 NCBI Gene Model | MGI Sequence Detail 3679 C57BL/6J ±  kb
    transcript NM_011315 RefSeq | MGI Sequence Detail 531 ZRU/MplStud  
    polypeptide P04918 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 12
      cDNA 14
      Primer pair 2
      Other 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14275, MGD-MRK-14280, MGI:1890512, MGI:2142177
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:17551 Stearman RS, et al., Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci. 1982;389:106-15
    • Latest
      J:389438 Srinivasan T, et al., The gut microbiota directs vitamin A flux to regulate intestinal T cell development. Cell Host Microbe. 2026 Jun 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory