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Rps6 Gene Detail
Summary
  • Symbol
    Rps6
  • Name
    ribosomal protein S6
  • Synonyms
    S6R
  • Feature Type
    protein coding gene
  • IDs
    MGI:98159
    NCBI Gene: 20104
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86772897-86775649 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98159
 protein coding gene Chr4:86772336-86775649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028415
 protein coding gene Chr4:86633283-86636035 (-)
A/J MGP_AJ_G0028376
 protein coding gene Chr4:83663457-83665927 (-)
AKR/J MGP_AKRJ_G0028325
 protein coding gene Chr4:85729781-85733433 (-)
BALB/cJ MGP_BALBcJ_G0028396
 protein coding gene Chr4:83840703-83845040 (-)
C3H/HeJ MGP_C3HHeJ_G0028111
 protein coding gene Chr4:86407220-86410813 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028835
 protein coding gene Chr4:89968045-89974264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026135
 protein coding gene Chr4:79698301-79701082 (-)
CAST/EiJ MGP_CASTEiJ_G0027552
 protein coding gene Chr4:84263683-84269444 (-)
CBA/J MGP_CBAJ_G0028080
 protein coding gene Chr4:92714270-92716922 (-)
DBA/2J MGP_DBA2J_G0028229
 protein coding gene Chr4:83399040-83401695 (-)
FVB/NJ MGP_FVBNJ_G0028195
 protein coding gene Chr4:82376062-82378690 (-)
LP/J MGP_LPJ_G0028329
 protein coding gene Chr4:86979952-86984037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028224
 protein coding gene Chr4:97771892-97776643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028872
 protein coding gene Chr4:85817165-85820737 (-)
PWK/PhJ MGP_PWKPhJ_G0027275
 protein coding gene Chr4:81715686-81718359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027100
 protein coding gene Chr4:83352545-83357562 (-)
WSB/EiJ MGP_WSBEiJ_G0027628
 protein coding gene Chr4:86021948-86024751 (-)



Homology
more
  • Human Ortholog
    RPS6, ribosomal protein S6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6, ribosomal protein S6
  • Synonyms
    eS6, S6
  • Links
    NCBI Gene ID: 6194
    neXtProt AC: NX_P62753
    UniProt: P62753

  • Chr Location
    9p22.1; chr9:19375715-19380236 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with an inducible, liver-specific null mutation exhibit failure of liver regeneration and an absence of 40S ribosomes in hepatocytes. Mice with a mutation where serines are unphosphorylatable exhibit hypoinsulinemia, impaired glucose tolerance, and smaller MEFs and beta cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    53
  • cDNA Data
    28
  • Literature Summary
    126
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028495 Ensembl Gene Model | MGI Sequence Detail 2753 C57BL/6J ±  kb
    transcript ENSMUST00000102814 Ensembl | MGI Sequence Detail 878 Not Applicable  
    polypeptide ENSMUSP00000099878 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 30
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-14186
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 126
      Gene Ontology 18
      Phenotypes 26
    • Earliest
      J:8776 Lalanne JL, et al., Complete sequence of mouse S6 ribosomal protein. Nucleic Acids Res. 1987 Jun 25;15(12):4990
    • Latest
      J:344838 Sharma S, et al., Uncovering a mammalian neural-specific poly(A) binding protein with unique properties. Genes Dev. 2023 Aug 1;37(15-16):760-777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory