Rps14 MGI Mouse Gene Detail - MGI:98107

Symbol

Rps14
Name

ribosomal protein S14
Synonyms

2600014J02Rik

Feature Type

protein coding gene
IDs

MGI:98107
NCBI Gene: 20044
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:60907668-60911618 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.40 cM
Mapping Data

2 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98107	protein coding gene	Chr18:60880170-60911618 (+)
129S1/SvImJ	ENSMUSG00200030755	protein coding gene	Chr18:58068715-58072751 (+)
A/J	ENSMUSG00195005221	protein coding gene	Chr18:58130459-58134612 (+)
AKR/J	ENSMUSG00220015951	protein coding gene	Chr18:58124185-58128223 (+)
BALB/cJ	ENSMUSG00180011645	protein coding gene	Chr18:58702120-58706271 (+)
C3H/HeJ	ENSMUSG00175031903	protein coding gene	Chr18:58320089-58324125 (+)
C57BL/6NJ	ENSMUSG00215036686	protein coding gene	Chr18:57639967-57644003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022311	protein coding gene	Chr18:57559131-57563229 (+)
CAST/EiJ	ENSTCUG00005026690	protein coding gene	Chr18:57339916-57343980 (+)
CBA/J	ENSMUSG00210030970	protein coding gene	Chr18:58264810-58268959 (+)
DBA/2J	ENSMUSG00185014317	protein coding gene	Chr18:58167364-58171400 (+)
FVB/NJ	ENSMUSG00205016251	protein coding gene	Chr18:57651555-57655597 (+)
JF1/MsJ	ENSUMUG00000017433	protein coding gene	Chr18:58032543-58036596 (+)
LP/J	ENSMUSG00230009260	protein coding gene	Chr18:60228380-60232416 (+)
NOD/ShiLtJ	ENSMUSG00190027857	protein coding gene	Chr18:57921170-57925223 (+)
NZO/HlLtJ	ENSMUSG00225035002	protein coding gene	Chr18:60104946-60108982 (+)
PWK/PhJ	ENSLUMG00010008321	protein coding gene	Chr18:58450757-58454820 (+)
SPRET/EiJ	ENSMSPG00010016193	protein coding gene	Chr18:58697565-58701620 (+)
WSB/EiJ	ENSIUOG00005008834	protein coding gene	Chr18:57794405-57798441 (+)

Human Ortholog

RPS14, ribosomal protein S14

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS14, ribosomal protein S14
Synonyms

EMTB, S14, uS11
Links

HGNC:10387

NCBI Gene ID: 6208

UniProt: P62263
Chr Location

5q33.1; chr5:150442635-150449952 (-) GRCh38

MGI Vertebrate Homology

Rps14 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS14
Protein SuperFamily

Ribosomal_S11
Gene Tree

Rps14

Diseases

1 with human RPS14 associations

				Human Disease	Mouse Models
				chromosome 5q deletion syndrome IDs chromosome 5q deletion syndrome DOID:0090016 ICD10CM:D46.7 MESH:C535323 OMIM:153550 ORDO:86841

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

114
Endonuclease-mediated

1
Gene trapped

110
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Conditional heterozygous knockout in hematopoietic cells leads to reduced protein synthesis, resulting in progressive anemia.

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All GO Annotations

59
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

605
Tissues

5
cDNA Data

675
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps14

ZFIN rps14

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All Sequences

70
RefSeq

2
UniProt

5
CCDS

CCDS29274.1

Ensembl

ENSMUSG00000024608 (Evidence)
NCBI Gene

20044

			Length	Strain/Species	Flank
genomic	20044	NCBI Gene Model \| MGI Sequence Detail	3951	C57BL/6J	± kb
transcript	NM_020600	RefSeq \| MGI Sequence Detail	606	ZRU/MplStud
polypeptide	P62264	UniProt \| EBI \| MGI Sequence Detail	151	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014255 eukaryotic-type small ribosomal subunit protein uS11

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2, 9H4N, 9QOH, 9QQL, 9QQP, 9QSA, 9QWT
InterPro Domains

IPR001971 Small ribosomal subunit protein uS11

IPR018102 Small ribosomal subunit protein uS11, conserved site

IPR036967 Small ribosomal subunit protein uS11 superfamily
GlyGen

P62264 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 677

cDNA 676

Primer pair 1

Antibodies 1

Microarray probesets 4

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MGD-MRK-14133, MGI:1914326, MGI:2139854

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 12
Earliest

J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
Latest

J:361593 Wang Q, et al., Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells. J Clin Invest. 2025 Feb 3;135(3)

TSS for Rps14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151323	Chr18:60907686-60907697 (+)	24 bp
Tssr151324	Chr18:60907698-60907735 (+)	49 bp
Tssr151325	Chr18:60907747-60907758 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24