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Pdc Gene Detail
Summary
  • Symbol
    Pdc
  • Name
    phosducin
  • Synonyms
    Pdc, Rpr-1, Rpr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98090
    NCBI Gene: 20028
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:150195168-150209657 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    635 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98090
 protein coding gene Chr1:150195168-150209657 (+)
129S1/SvImJ ENSMUSG00200002269
 protein coding gene Chr1:147657479-147671972 (+)
A/J ENSMUSG00195012946
 protein coding gene Chr1:147000793-147015258 (+)
AKR/J ENSMUSG00220005259
 protein coding gene Chr1:146770075-146784850 (+)
BALB/cJ ENSMUSG00180029869
 protein coding gene Chr1:147212633-147227123 (+)
C3H/HeJ ENSMUSG00175002610
 protein coding gene Chr1:147252583-147267039 (+)
C57BL/6NJ ENSMUSG00215003451
 protein coding gene Chr1:147154777-147169266 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014686
 protein coding gene Chr1:141085319-141101093 (+)
CAST/EiJ ENSTCUG00005005869
 protein coding gene Chr1:145788597-145803483 (+)
CBA/J ENSMUSG00210032263
 protein coding gene Chr1:147149609-147164073 (+)
DBA/2J ENSMUSG00185006983
 protein coding gene Chr1:151420243-151434713 (+)
FVB/NJ ENSMUSG00205018057
 protein coding gene Chr1:146297072-146311557 (+)
JF1/MsJ ENSUMUG00000008160
 protein coding gene Chr1:150571540-150586425 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190011973
 protein coding gene Chr1:146998257-147012751 (+)
NZO/HlLtJ ENSMUSG00225005300
 protein coding gene Chr1:154698991-154713484 (+)
PWK/PhJ ENSLUMG00010027549
 protein coding gene Chr1:145938543-145953302 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005023604
 protein coding gene Chr1:146594319-146608812 (+)



Homology
more
  • Human Ortholog
    PDC, phosducin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDC, phosducin
  • Synonyms
    MEKA, PHD, PhLOP, PhLP
  • Links
    NCBI Gene ID: 5132
    UniProt: P20941

  • Chr Location
    1q31.1; chr1:186443566-186461114 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal retinal morphology and rod function with reduced transducin (Gnat1) translocation. Mice homozygous for a different knock-out allele exhibit large pupils, increased blood pressure, age-related vascular smooth muscle hypertrophy, and stress-induced hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    675
  • Tissues
    16
  • cDNA Data
    106
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20028 NCBI Gene Model | MGI Sequence Detail 14490 C57BL/6J ±  kb
    transcript NM_001159730 RefSeq | MGI Sequence Detail 1263 ZRU/MplStud  
    polypeptide Q9QW08 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 1
      cDNA 108
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13205, MGD-MRK-14115, MGD-MRK-14116
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:11278 Danciger M, et al., The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2. Cytogenet Cell Genet. 1991;56(3-4):202-5
    • Latest
      J:301112 Maddala R, et al., Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory