Rnu2-10 Gene Detail

Summary

• Symbol
  Rnu2-10
• Name
  U2 small nuclear RNA 10
• Synonyms
  Rnu2

• Feature Type
  snRNA gene
• IDs
  MGI:97976
  NCBI Gene: 19848
• Alliance
  genome feature page

Location &
Maps

• Sequence Map
  Chr11:101549064-101549250 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 65.48 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  188 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97976	snRNA gene	Chr11:101549064-101549254 (+)
129S1/SvImJ	ENSMUSG00200053212	snRNA gene	Chr11:98833549-98833739 (+)
A/J	ENSMUSG00195052914	snRNA gene	Chr11:98530225-98530415 (+)
AKR/J	ENSMUSG00220052864	snRNA gene	Chr11:98749474-98749664 (+)
BALB/cJ	ENSMUSG00180052186	snRNA gene	Chr11:98881695-98881885 (+)
C3H/HeJ	ENSMUSG00175052477	snRNA gene	Chr11:98807088-98807278 (+)
C57BL/6NJ	ENSMUSG00215054177	snRNA gene	Chr11:98369109-98369299 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005050730	snRNA gene	Chr11:98295615-98295805 (+)
CBA/J	ENSMUSG00210053762	snRNA gene	Chr11:98514940-98515130 (+)
DBA/2J	ENSMUSG00185053668	snRNA gene	Chr11:98856939-98857129 (+)
FVB/NJ	ENSMUSG00205049936	snRNA gene	Chr11:98699803-98699993 (+)
JF1/MsJ	ENSUMUG00000056065	snRNA gene	Chr11:99116903-99117093 (+)
LP/J	ENSMUSG00230051104	snRNA gene	Chr11:99909571-99909761 (+)
NOD/ShiLtJ	ENSMUSG00190053004	snRNA gene	Chr11:98895494-98895684 (+)
NZO/HlLtJ	ENSMUSG00225053585	snRNA gene	Chr11:101931785-101931975 (+)
PWK/PhJ	ENSLUMG00010052790	snRNA gene	Chr11:98651245-98651435 (+)
SPRET/EiJ	ENSMSPG00010051303	snRNA gene	Chr11:99148849-99149039 (+)
WSB/EiJ	ENSIUOG00005051364	snRNA gene	Chr11:98643664-98643854 (+)

Homology

• Gene Tree
  Rnu2-10
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Genomic Mutations
  1 involving Rnu2-10
• Find Mice (IMSR)
  0 strains or lines available

Subtle gait abnormalities, i.e., walking on the toes of the hind feet and a slight side-to-side sway, progress by approximately 11 weeks of age to a splay-legged, staggering walk with a pronounce side-to-side sway that sometimes causes the animal to loseits balance and fall over.

Expression

• Assay Results
  9
• Tissues
  1
• Literature Summary
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  23
• RefSeq
  1

• Ensembl
  ENSMUSG00000118837 (Evidence)
• NCBI Gene
  19848

Representative Sequences			Length	Strain/Species
genomic	19848	NCBI Gene Model | MGI Sequence Detail	187	C57BL/6J
transcript	NR_004414	RefSeq | MGI Sequence Detail	187	Swiss Webster

Molecular
Reagents

• All nucleic 2

  Primer pair 2

  
  

  Microarray probesets 7

Other
Accession IDs

MGD-MRK-13973, MGI:3054724

References

• Summaries
  All 18

  Developmental Gene Expression 2

  Phenotypes 5
• Earliest
  J:7100 Nojima H, et al., Genes and pseudogenes for mouse U1 and U2 small nuclear RNAs. J Biol Chem. 1983 Jul 10;258(13):8151-5
• Latest
  J:304858 Olthof AM, et al., Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucleic Acids Res. 2021 Apr 6;49(6):3524-3545