Rmrp MGI Mouse Gene Detail - MGI:97937 - RNA component of mitochondrial RNAase P

Symbol

Rmrp
Name

RNA component of mitochondrial RNAase P
Synonyms

Rmrpr, RNase MRP

Feature Type

RNase MRP RNA gene

BioType Conflict
IDs

MGI:97937
NCBI Gene: 19782
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:43492785-43493059 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.04 cM
Mapping Data

3 experiments

SNPs within 2kb

96 from dbSNP Build 142
Strain Annotations

35

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	no annotation		Chr4:43492783-43493063 (-)
129S1/SvImJ	ENSMUSG00200005665	lncRNA gene	Chr4:39528567-39528847 (-)
129S1/SvImJ	ENSMUSG00200005516	ribozyme gene	Chr4:39528572-39528842 (-)
A/J	ENSMUSG00195003723	lncRNA gene	Chr4:40001576-40001856 (-)
A/J	ENSMUSG00195003688	ribozyme gene	Chr4:40001581-40001851 (-)
AKR/J	ENSMUSG00220037361	ribozyme gene	Chr4:39688902-39689172 (-)
AKR/J	ENSMUSG00220036460	lncRNA gene	Chr4:39688897-39689177 (-)
BALB/cJ	ENSMUSG00180026606	lncRNA gene	Chr4:39588337-39588617 (-)
BALB/cJ	ENSMUSG00180028464	ribozyme gene	Chr4:39588342-39588612 (-)
C3H/HeJ	ENSMUSG00175023420	ribozyme gene	Chr4:39732662-39732932 (-)
C3H/HeJ	ENSMUSG00175023894	lncRNA gene	Chr4:39732657-39732937 (-)
C57BL/6NJ	ENSMUSG00215034658	ribozyme gene	Chr4:39513118-39513388 (-)
C57BL/6NJ	ENSMUSG00215030856	lncRNA gene	Chr4:39513113-39513393 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0034356	ribozyme gene	Chr4:37581612-37581882 (-)
CAST/EiJ	ENSTCUG00005004792	lncRNA gene	Chr4:39773214-39773494 (-)
CAST/EiJ	ENSTCUG00005004805	ribozyme gene	Chr4:39773219-39773489 (-)
CBA/J	ENSMUSG00210008280	ribozyme gene	Chr4:39423469-39423739 (-)
CBA/J	ENSMUSG00210008295	lncRNA gene	Chr4:39423464-39423744 (-)
DBA/2J	ENSMUSG00185006741	ribozyme gene	Chr4:39786895-39787165 (-)
DBA/2J	ENSMUSG00185006692	lncRNA gene	Chr4:39786890-39787170 (-)
FVB/NJ	ENSMUSG00205027919	ribozyme gene	Chr4:39030173-39030443 (-)
FVB/NJ	ENSMUSG00205027804	lncRNA gene	Chr4:39030168-39030448 (-)
JF1/MsJ	ENSUMUG00000031120	ribozyme gene	Chr4:40024881-40025151 (-)
JF1/MsJ	ENSUMUG00000028746	lncRNA gene	Chr4:40024876-40025154 (-)
LP/J	ENSMUSG00230042608	lncRNA gene	Chr4:43340965-43341245 (-)
LP/J	ENSMUSG00230042584	ribozyme gene	Chr4:43340970-43341240 (-)
NOD/ShiLtJ	ENSMUSG00190006042	ribozyme gene	Chr4:39647219-39647489 (-)
NOD/ShiLtJ	ENSMUSG00190006267	lncRNA gene	Chr4:39647214-39647494 (-)
NZO/HlLtJ	ENSMUSG00225007302	lncRNA gene	Chr4:47928232-47928512 (-)
NZO/HlLtJ	ENSMUSG00225007296	ribozyme gene	Chr4:47928237-47928507 (-)
PWK/PhJ	ENSLUMG00010006779	lncRNA gene	Chr4:39026310-39026590 (-)
PWK/PhJ	ENSLUMG00010006736	ribozyme gene	Chr4:39026315-39026585 (-)
SPRET/EiJ	ENSMSPG00010025518	lncRNA gene	Chr4:39963042-39963322 (-)
SPRET/EiJ	ENSMSPG00010026207	ribozyme gene	Chr4:39963047-39963317 (-)
WSB/EiJ	ENSIUOG00005049791	ribozyme gene	Chr4:39400079-39400349 (-)
WSB/EiJ	ENSIUOG00005049829	lncRNA gene	Chr4:39400074-39400354 (-)

Human Ortholog

RMRP, RNA component of mitochondrial RNA processing endoribonuclease

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RMRP, RNA component of mitochondrial RNA processing endoribonuclease
Synonyms

CHH, NME1, RMRPR, RRP2
Links

HGNC:10031

NCBI Gene ID: 6023
Chr Location

9p13.3; chr9:35657750-35658019 (-) GRCh38

MGI Vertebrate Homology

Rmrp stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: RMRP

Diseases

2 with human RMRP associations

				Human Disease	Mouse Models
				anauxetic dysplasia 1 IDs anauxetic dysplasia 1 DOID:0050640 OMIM:607095
				cartilage-hair hypoplasia IDs cartilage-hair hypoplasia DOID:14773 MESH:C535916 NCI:C61245 OMIM:250250 UMLS_CUI:C0220748

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality.

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

5
cDNA Data

1
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

42
RefSeq

1

Ensembl

ENSMUSG00000088088 (Evidence), ENSMUSG00000115420 (Evidence)
NCBI Gene

19782

Representative Sequences				Length	Strain/Species	Flank
	genomic	19782	NCBI Gene Model \| MGI Sequence Detail	275	C57BL/6J	± kb
	transcript	NR_001460	RefSeq \| MGI Sequence Detail	275	Not Specified

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All nucleic 4

Genomic 1

cDNA 1

Primer pair 1

Other 1

Microarray probesets 1

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MGD-MRK-13907, MGD-MRK-13908

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:12493 Hsieh CL, et al., The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human Chromosome 9p and on mouse Chromosome 4. Cytogenet Cell Genet. 1989;51:1016 (Abstr.)
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Rmrp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41424	Chr4:43493051-43493065 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24