Rbp2 MGI Mouse Gene Detail - MGI:97877 - retinol binding protein 2, cellular

Symbol

Rbp2
Name

retinol binding protein 2, cellular
Synonyms

Crbp-2, CrbpII, Rbp-2

Feature Type

protein coding gene
IDs

MGI:97877
NCBI Gene: 19660
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:98372590-98391824 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 51.37 cM
Mapping Data

11 experiments

SNPs within 2kb

660 from dbSNP Build 142
Strain Annotations

19
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97877	protein coding gene	Chr9:98368168-98391834 (+)
129S1/SvImJ	ENSMUSG00200016282	protein coding gene	Chr9:95488247-95512050 (+)
A/J	ENSMUSG00195016670	protein coding gene	Chr9:94739501-94763235 (+)
AKR/J	ENSMUSG00220034202	protein coding gene	Chr9:95113235-95137003 (+)
BALB/cJ	ENSMUSG00180019189	protein coding gene	Chr9:95059139-95082877 (+)
C3H/HeJ	ENSMUSG00175012535	protein coding gene	Chr9:95401990-95425723 (+)
C57BL/6NJ	ENSMUSG00215021242	protein coding gene	Chr9:95385873-95409547 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032548	protein coding gene	Chr9:94051357-94075221 (+)
CAST/EiJ	ENSTCUG00005012890	protein coding gene	Chr9:95220050-95243871 (+)
CBA/J	ENSMUSG00210014593	protein coding gene	Chr9:95240252-95264051 (+)
DBA/2J	ENSMUSG00185011389	protein coding gene	Chr9:95426658-95450383 (+)
FVB/NJ	ENSMUSG00205014246	protein coding gene	Chr9:95432712-95456500 (+)
JF1/MsJ	ENSUMUG00000020507	protein coding gene	Chr9:95189170-95212895 (+)
LP/J	ENSMUSG00230017212	protein coding gene	Chr9:95594654-95618445 (+)
NOD/ShiLtJ	ENSMUSG00190030612	protein coding gene	Chr9:95061890-95085621 (+)
NZO/HlLtJ	ENSMUSG00225017887	protein coding gene	Chr9:95752889-95772307 (+)
PWK/PhJ	ENSLUMG00010025455	protein coding gene	Chr9:95175384-95198872 (+)
SPRET/EiJ	ENSMSPG00010003715	protein coding gene	Chr9:96974692-96998496 (+)
WSB/EiJ	ENSIUOG00005023727	protein coding gene	Chr9:94497287-94521051 (+)

Human Ortholog

RBP2, retinol binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBP2, retinol binding protein 2
Synonyms

CRABP-II, CRBP2, CRBP-II, CRBPII, RBPC2
Links

HGNC:9920

NCBI Gene ID: 5948

UniProt: P50120
Chr Location

3q23; chr3:139452884-139480767 (-) GRCh38

MGI Vertebrate Homology

Rbp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBP2
Gene Tree

Rbp2

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Rbp2
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available

Saturable vitamin A (retinol) uptake is impaired in homozygous mutant mice. Serum retinol levels are unaffected when with normal dietary intake, however, pups of homozygous dams fed a marginal retinol diet show increased neonatal lethality due to inadequate retinal transport to the fetus.

less

All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

615
Tissues

11
cDNA Data

70
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbp2

ZFIN rbp2a, rbp2b

less

All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS23425.1

Ensembl

ENSMUSG00000032454 (Evidence)
NCBI Gene

19660

			Length	Strain/Species	Flank
genomic	19660	NCBI Gene Model \| MGI Sequence Detail	19235	C57BL/6J	± kb
transcript	NM_009034	RefSeq \| MGI Sequence Detail	672	ZRU/MplStud
polypeptide	Q08652	UniProt \| EBI \| MGI Sequence Detail	134	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000013819 retinol-binding protein 2

(term hierarchy)
InterPro Domains

IPR012674 Calycin superfamily

IPR000463 Cytosolic fatty-acid binding

IPR031259 Intracellular lipid binding protein

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

less

All nucleic 77

Genomic 2

cDNA 71

Primer pair 3

Other 1

Antibodies 1

Microarray probesets 3

less

MGD-MRK-13788, MGD-MRK-13793, MGD-MRK-2132

Summaries

All 68

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 11
Earliest

J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
Latest

J:357965 Calderon RM, et al., Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein 2 and Retinoid Actions. Endocrinology. 2022 Jul 1;163(7)

TSS for Rbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86654	Chr9:98372406-98372425 (+)	-174 bp
Tssr86655	Chr9:98372575-98372589 (+)	-8 bp
Tssr86656	Chr9:98372598-98372615 (+)	17 bp
Tssr86657	Chr9:98380760-98380788 (+)	8,184 bp
Tssr86658	Chr9:98386807-98386819 (+)	14,223 bp
Tssr2985	Chr9:98386998-98387009 (+)	14,414 bp
Tssr86659	Chr9:98391716-98391736 (+)	19,136 bp
Tssr86660	Chr9:98391780-98391791 (+)	19,196 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24