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Qki Gene Detail
Summary
  • Symbol
    Qki
  • Name
    quaking, KH domain containing RNA binding
  • Synonyms
    1110003F05Rik, l(17)-1Wis, l17Wis1, Qk, QkI
  • Feature Type
    protein coding gene
  • IDs
    MGI:97837
    NCBI Gene: 19317
  • Alliance
    genome feature page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:10425480-10538706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 7.75 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1547 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97837
 protein coding gene Chr17:10421530-10538783 (-)
129S1/SvImJ ENSMUSG00200030297
 protein coding gene Chr17:6664210-6781472 (-)
A/J ENSMUSG00195023315
 protein coding gene Chr17:6862396-6979781 (-)
AKR/J ENSMUSG00220025163
 protein coding gene Chr17:6916115-7033552 (-)
BALB/cJ ENSMUSG00180021425
 protein coding gene Chr17:6499137-6616573 (-)
C3H/HeJ ENSMUSG00175031768
 protein coding gene Chr17:6652728-6770116 (-)
C57BL/6NJ ENSMUSG00215026569
 protein coding gene Chr17:6689283-6806667 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021057
 protein coding gene Chr17:6600656-6709475 (+)
CAST/EiJ ENSTCUG00005021195
 protein coding gene Chr17:6880995-7002374 (-)
CBA/J ENSMUSG00210035763
 protein coding gene Chr17:6319409-6436786 (-)
DBA/2J ENSMUSG00185022324
 protein coding gene Chr17:7412201-7529590 (-)
FVB/NJ ENSMUSG00205007453
 protein coding gene Chr17:6727563-6844922 (-)
JF1/MsJ ENSUMUG00000020556
 protein coding gene Chr17:7000093-7117741 (-)
LP/J ENSMUSG00230031287
 protein coding gene Chr17:8834475-8951890 (-)
NOD/ShiLtJ ENSMUSG00190025431
 protein coding gene Chr17:6833928-6951310 (-)
NZO/HlLtJ ENSMUSG00225047353
 protein coding gene Chr17:10753391-10870796 (-)
PWK/PhJ ENSLUMG00010018683
 protein coding gene Chr17:6827569-6945053 (-)
SPRET/EiJ ENSMSPG00010034065
 protein coding gene Chr17:6748683-6861979 (+)
WSB/EiJ ENSIUOG00005013493
 protein coding gene Chr17:6722164-6839549 (-)



Homology
more
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
  • Synonyms
    Hqk, hqkI, QK, QK1, QK3
  • Links
    NCBI Gene ID: 9444
    UniProt: Q96PU8

  • Chr Location
    6q26; chr6:163414000-163578592 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 8 alleles in 11 genetic backgrounds
    26 phenotypes from multigenic genotypes
    3 images
    517 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1116
  • Tissues
    116
  • cDNA Data
    29
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19317 NCBI Gene Model | MGI Sequence Detail 113227 C57BL/6J ±  kb
    transcript NM_021881 RefSeq | MGI Sequence Detail 6658 ZRU/MplStud  
    polypeptide Q9QYS9 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013564 KH domain-containing RNA-binding protein QKI
      (term hierarchy)
    • PDB
      4DNN
    • InterPro Domains
      IPR055256 KHDC4/BBP-like, KH-domain type I
      IPR045071 KH domain-containing BBP-like
      IPR004087 K Homology domain
      IPR036612 K Homology domain, type 1 superfamily
      IPR032367 Protein quaking, putative nuclear localisation signal
      IPR032377 STAR protein, homodimerisation region
    • GlyGen
      Q9QYS9 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 9
      cDNA 30
      Primer pair 6
      Other 2
      Antibodies 1

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:7256376, MGI:96711
    References
    more
    • Summaries
      All 603
      Developmental Gene Expression 24
      Diseases 6
      Gene Ontology 35
      Phenotypes 517
    • Earliest
      J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory