About   Help   FAQ
Ppib Gene Detail
Summary
  • Symbol
    Ppib
  • Name
    peptidylprolyl isomerase B
  • Synonyms
    Cphn-2, Cphn2, cyclophilin B, CyP-20b
  • Feature Type
    protein coding gene
  • IDs
    MGI:97750
    NCBI Gene: 19035
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65967504-65973905 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97750
 protein coding gene Chr9:65967451-65973911 (+)
129S1/SvImJ ENSMUSG00200041649
 protein coding gene Chr9:63062853-63070054 (+)
A/J ENSMUSG00195025358
 protein coding gene Chr9:62786957-62794175 (+)
AKR/J ENSMUSG00220038501
 protein coding gene Chr9:62924978-62932198 (+)
BALB/cJ ENSMUSG00180015000
 protein coding gene Chr9:62913585-62920803 (+)
C3H/HeJ ENSMUSG00175011137
 protein coding gene Chr9:62920301-62927519 (+)
C57BL/6NJ ENSMUSG00215024416
 protein coding gene Chr9:62908408-62915608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032373
 protein coding gene Chr9:63266080-63272227 (+)
CAST/EiJ ENSTCUG00005026178
 protein coding gene Chr9:62823654-62830434 (+)
CBA/J ENSMUSG00210013791
 protein coding gene Chr9:63005645-63012845 (+)
DBA/2J ENSMUSG00185032575
 protein coding gene Chr9:63032942-63039724 (+)
FVB/NJ ENSMUSG00205028780
 protein coding gene Chr9:63352037-63358789 (+)
JF1/MsJ ENSUMUG00000025292
 protein coding gene Chr9:63097786-63104532 (+)
LP/J ENSMUSG00230023654
 protein coding gene Chr9:63261756-63268300 (+)
NOD/ShiLtJ ENSMUSG00190022164
 protein coding gene Chr9:63116345-63123516 (+)
NZO/HlLtJ ENSMUSG00225044367
 protein coding gene Chr9:63331790-63338332 (+)
PWK/PhJ ENSLUMG00010024912
 protein coding gene Chr9:63048814-63055563 (+)
SPRET/EiJ ENSMSPG00010021208
 protein coding gene Chr9:64120060-64126764 (+)
WSB/EiJ ENSIUOG00005023074
 protein coding gene Chr9:62521075-62528275 (+)



Homology
more
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIB, peptidylprolyl isomerase B
  • Synonyms
    CYPB, CYP-S1, HEL-S-39, OI9, SCYLP
  • Links
    NCBI Gene ID: 5479
    UniProt: P23284

  • Chr Location
    15q22.31; chr15:64155740-64163159 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppib mouse models; 1 with human PPIB associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null mutations develop kyphosis and severe osteoporosis. Bone structure abnormalities are also seen in the trabecular and cortical regions of the long bones. Bone mineral density is reduced, and bones have reduced strength and are susceptible to fractures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    16
  • cDNA Data
    200
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032383 Ensembl Gene Model | MGI Sequence Detail 6402 C57BL/6J ±  kb
    transcript ENSMUST00000034947 Ensembl | MGI Sequence Detail 892 Not Applicable  
    polypeptide ENSMUSP00000034947 Ensembl | MGI Sequence Detail 216 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013076 eukaryotic peptidyl-prolyl cis-trans isomerase B
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    • GlyGen
      P24369 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 206
      cDNA 200
      Primer pair 2
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13592, MGD-MRK-2109, MGD-MRK-2110, MGI:2142929, MGI:2142956, MGI:2143139
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 18
      Diseases 2
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:2339 Schumacher A, et al., Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991 Dec 2;1129(1):13-22
    • Latest
      J:385698 Molotkova A, et al., ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis. Cancer Res Commun. 2026 Mar 1;6(3):477-499
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory