Plk1 MGI Mouse Gene Detail - MGI:97621

Symbol

Plk1
Name

polo like kinase 1
Synonyms

Plk, STPK13

Feature Type

protein coding gene
IDs

MGI:97621
NCBI Gene: 18817
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:121758662-121769096 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 65.52 cM
Mapping Data

11 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97621	protein coding gene	Chr7:121758658-121769107 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032953	protein coding gene	Chr7:126234993-126246281 (+)
A/J	MGP_AJ_G0032936	protein coding gene	Chr7:122959820-122971599 (+)
AKR/J	MGP_AKRJ_G0032868	protein coding gene	Chr7:126086555-126098968 (+)
BALB/cJ	MGP_BALBcJ_G0032941	protein coding gene	Chr7:122653122-122663512 (+)
C3H/HeJ	MGP_C3HHeJ_G0032651	protein coding gene	Chr7:126009232-126020692 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033447	protein coding gene	Chr7:131210462-131221290 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030419	protein coding gene	Chr7:124285923-124296276 (+)
CAST/EiJ	MGP_CASTEiJ_G0031979	protein coding gene	Chr7:117801001-117813642 (+)
CBA/J	MGP_CBAJ_G0032624	protein coding gene	Chr7:135619031-135636283 (+)
DBA/2J	MGP_DBA2J_G0032776	protein coding gene	Chr7:120962428-120972846 (+)
FVB/NJ	MGP_FVBNJ_G0032729	protein coding gene	Chr7:120814109-120824723 (+)
LP/J	MGP_LPJ_G0032870	protein coding gene	Chr7:127674575-127685866 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032761	protein coding gene	Chr7:136987376-137001427 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033467	protein coding gene	Chr7:125094019-125105756 (+)
PWK/PhJ	MGP_PWKPhJ_G0031687	protein coding gene	Chr7:113891941-113903146 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031533	protein coding gene	Chr7:111870011-111880539 (+)
WSB/EiJ	MGP_WSBEiJ_G0032092	protein coding gene	Chr7:125998339-126010955 (+)

Human Ortholog

PLK1, polo like kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLK1, polo like kinase 1
Synonyms

PLK, STPK13
Links

HGNC:9077

NCBI Gene ID: 5347

neXtProt AC: NX_P53350

UniProt: P53350
Chr Location

16p12.2; chr16:23677656-23690367 (+) GRCh38

MGI Vertebrate Homology

Plk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLK1
Gene Tree

Plk1

Diseases

1 with human PLK1 associations

				Human Disease	Mouse Models
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

2
Gene trapped

13
Spontaneous

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display lethality before implantation, embryonic growth arrest, and impaired mitosis. Mice heterozygous for a null mutation display increased tumor incidence and increased incidence of aneuploidy.

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All GO Annotations

131
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

886
Tissues

141
cDNA Data

20
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plk1

ZFIN plk1

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All Sequences

54
RefSeq

2
UniProt

5
CCDS

CCDS21812.1

Ensembl

ENSMUSG00000030867 (Evidence)
NCBI Gene

18817

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030867	Ensembl Gene Model \| MGI Sequence Detail	10435	C57BL/6J	± kb
transcript	ENSMUST00000033154	Ensembl \| MGI Sequence Detail	2199	Not Applicable
polypeptide	ENSMUSP00000033154	Ensembl \| MGI Sequence Detail	603	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012870 serine/threonine-protein kinase PLK1

(term hierarchy)
PDB

5DMS, 5DMV, 5DNJ, 5X3S
EC

2.7.11.21
InterPro Domains

IPR033701 First polo-box domain

IPR000959 POLO box domain

IPR036947 POLO box domain superfamily

IPR033702 Polo-like kinase 1, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR033695 Second polo-box domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 38

Genomic 7

cDNA 22

Primer pair 7

Other 2

Microarray probesets 5

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MGD-MRK-13361

Summaries

All 152

Developmental Gene Expression 45

Gene Ontology 16

Phenotypes 26
Earliest

J:12876 Clay FJ, et al., Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6
Latest

J:346372 Kolesova H, et al., Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. Front Endocrinol (Lausanne). 2024;15:1344074

TSS for Plk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68864	Chr7:121758645-121758724 (+)	23 bp
Tssr68865	Chr7:121761628-121761670 (+)	2,987 bp
Tssr68866	Chr7:121763290-121763309 (+)	4,638 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23