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Prkacb Gene Detail
Summary
  • Symbol
    Prkacb
  • Name
    protein kinase, cAMP dependent, catalytic, beta
  • Synonyms
    cAMP-dependent protein kinase C beta, Pkacb
  • Feature Type
    protein coding gene
  • IDs
    MGI:97594
    NCBI Gene: 18749
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146435334-146518701 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 72.28 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    503 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97594
 protein coding gene Chr3:146435329-146518745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027979
 protein coding gene Chr3:150264697-150351041 (-)
A/J MGP_AJ_G0027938
 protein coding gene Chr3:144862254-144946687 (-)
AKR/J MGP_AKRJ_G0027904
 protein coding gene Chr3:148739838-148827749 (-)
BALB/cJ MGP_BALBcJ_G0027950
 protein coding gene Chr3:144685193-144770788 (-)
C3H/HeJ MGP_C3HHeJ_G0027680
 protein coding gene Chr3:149101237-149188941 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028393
 protein coding gene Chr3:155301472-155392324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025731
 protein coding gene Chr3:139917727-139998494 (-)
CAST/EiJ MGP_CASTEiJ_G0027133
 protein coding gene Chr3:149087613-149171895 (-)
CBA/J MGP_CBAJ_G0027655
 protein coding gene Chr3:160807935-160897380 (-)
DBA/2J MGP_DBA2J_G0027795
 protein coding gene Chr3:144017053-144101030 (-)
FVB/NJ MGP_FVBNJ_G0027762
 protein coding gene Chr3:141427785-141510901 (-)
LP/J MGP_LPJ_G0027906
 protein coding gene Chr3:151645117-151734348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027795
 protein coding gene Chr3:169076497-169161948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028452
 protein coding gene Chr3:148317001-148405175 (-)
PWK/PhJ MGP_PWKPhJ_G0026856
 protein coding gene Chr3:143881812-143966227 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026684
 protein coding gene Chr3:146479088-146618143 (-)
WSB/EiJ MGP_WSBEiJ_G0027213
 protein coding gene Chr3:149303196-149391748 (-)



Homology
more
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKACB, protein kinase cAMP-activated catalytic subunit beta
  • Synonyms
    CAFD2, PKACB, PKA C-beta
  • Links
    NCBI Gene ID: 5567
    neXtProt AC: NX_P22694
    UniProt: P22694

  • Chr Location
    1p31.1; chr1:84077975-84238498 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation eliminating the Cbeta1 subunit exhibit impaired hippocampal plasticity, including failure of low frequency stimulation to produce lasting depression and the elimination of mossy fiber long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    901
  • Tissues
    170
  • cDNA Data
    226
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18749 NCBI Gene Model | MGI Sequence Detail 83368 C57BL/6J ±  kb
    transcript NM_001164199 RefSeq | MGI Sequence Detail 4853 C57BL/6  
    polypeptide P68181 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 236
      Genomic 6
      cDNA 227
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13325
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:35384 Uhler MD, et al., Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase [published erratum appears in J Biol Chem 1987 Apr 15;262(11):5431]. J Biol Chem. 1986 Nov 25;261(33):15360-3
    • Latest
      J:307636 Li D, et al., RNF216 regulates meiosis and PKA stability in the testes. FASEB J. 2021 Apr;35(4):e21460
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/21/2023
    MGI 6.22     		The Jackson Laboratory