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Pam Gene Detail
Summary
  • Symbol
    Pam
  • Name
    peptidylglycine alpha-amidating monooxygenase
  • Synonyms
    PHM
  • Feature Type
    protein coding gene
  • IDs
    MGI:97475
    NCBI Gene: 18484
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:97748816-98023578 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.76 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7463 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97475
 protein coding gene Chr1:97722839-98023578 (-)
129S1/SvImJ ENSMUSG00200000205
 protein coding gene Chr1:94927494-95083714 (-)
A/J ENSMUSG00195000233
 protein coding gene Chr1:94459746-94615930 (-)
AKR/J ENSMUSG00220000171
 protein coding gene Chr1:94763674-94919889 (-)
BALB/cJ ENSMUSG00180005585
 protein coding gene Chr1:94767463-94923643 (-)
C3H/HeJ ENSMUSG00175005539
 protein coding gene Chr1:94667497-94823673 (-)
C57BL/6NJ ENSMUSG00215000332
 protein coding gene Chr1:94655797-94811965 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014478
 protein coding gene Chr1:90352457-90644671 (-)
CAST/EiJ ENSTCUG00005000091
 protein coding gene Chr1:94246277-94395819 (-)
CBA/J ENSMUSG00210000046
 protein coding gene Chr1:94517484-94673653 (-)
DBA/2J ENSMUSG00185013760
 protein coding gene Chr1:98984794-99141009 (-)
FVB/NJ ENSMUSG00205000786
 protein coding gene Chr1:93871034-94022702 (-)
JF1/MsJ ENSUMUG00000020080
 protein coding gene Chr1:97743868-97892949 (-)
LP/J ENSMUSG00230023583
 protein coding gene Chr1:98248366-98404562 (-)
NOD/ShiLtJ ENSMUSG00190000223
 protein coding gene Chr1:94573839-94730043 (-)
NZO/HlLtJ ENSMUSG00225002253
 protein coding gene Chr1:102160185-102316350 (-)
PWK/PhJ ENSLUMG00010006307
 protein coding gene Chr1:94108812-94272621 (-)
SPRET/EiJ ENSMSPG00010000732
 protein coding gene Chr1:96258830-96406838 (-)
WSB/EiJ ENSIUOG00005000250
 protein coding gene Chr1:94243898-94401082 (-)



Homology
more
  • Human Ortholog
    PAM, peptidylglycine alpha-amidating monooxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAM, peptidylglycine alpha-amidating monooxygenase
  • Synonyms
    PAL, PAM-1, PHM
  • Links
    NCBI Gene ID: 5066
    UniProt: P19021

  • Chr Location
    5q21.1; chr5:102753981-103031149 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development, edema, abnormal yolk sac vasculature, thin arterial walls, and abnormal bronchial epithelial morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    59
  • cDNA Data
    9
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18484 NCBI Gene Model | MGI Sequence Detail 274763 C57BL/6J ±  kb
    transcript NM_001357127 RefSeq | MGI Sequence Detail 3995 C57BL/6  
    polypeptide P97467 UniProt | EBI | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000012252 peptidyl-glycine alpha-amidating monooxygenase
      (term hierarchy)
    • EC
      1.14.17.3, 4.3.2.5
    • InterPro Domains
      IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
      IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
      IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
      IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
      IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
      IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
      IPR001258 NHL repeat
      IPR000720 Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
      IPR008977 PHM/PNGase F domain superfamily
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      P97467 2 sites
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13129
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:386526 Umapathysivam MM, et al., Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists. Genome Med. 2026 Mar 29;18(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory