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Orm2 Gene Detail
Summary
  • Symbol
    Orm2
  • Name
    orosomucoid 2
  • Synonyms
    Orm-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97444
    NCBI Gene: 18406
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63280686-63284115 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 33.96 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97444
protein coding gene Chr4:63280543-63284115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028366
protein coding gene Chr4:62367302-62370721 (+)
A/J MGP_AJ_G0028327
protein coding gene Chr4:60125568-60128985 (+)
AKR/J MGP_AKRJ_G0028277
protein coding gene Chr4:61766005-61769422 (+)
BALB/cJ MGP_BALBcJ_G0028347
protein coding gene Chr4:60314221-60317692 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028787
protein coding gene Chr4:64507646-64511077 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027501
protein coding gene Chr4:60268736-60272152 (+)
CBA/J MGP_CBAJ_G0028032
protein coding gene Chr4:66764706-66769532 (+)
DBA/2J MGP_DBA2J_G0028181
protein coding gene Chr4:59979428-59982844 (+)
FVB/NJ MGP_FVBNJ_G0028146
protein coding gene Chr4:59255087-59258508 (+)
LP/J MGP_LPJ_G0028279
protein coding gene Chr4:62646459-62651531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028175
protein coding gene Chr4:69876683-69880988 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028823
protein coding gene Chr4:61873237-61876656 (+)
PWK/PhJ MGP_PWKPhJ_G0027230
protein coding gene Chr4:58511524-58515711 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027581
protein coding gene Chr4:61900067-61902024 (+)



Homology
more
  • Human Ortholog
    ORM1, orosomucoid 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORM1, orosomucoid 1
  • Synonyms
    AGP1, AGP-A, HEL-S-153w, ORM
  • Links
    NCBI Gene ID: 5004
    neXtProt AC: NX_P02763
    UniProt: P02763

  • Chr Location
    9q32; chr9:114323023-114326479 (+)  GRCh38.p7

  • Human Ortholog
    ORM2, orosomucoid 2
  • Synonyms
    AGP2, AGP-B, AGP-B'
  • Links
    NCBI Gene ID: 5005
    neXtProt AC: NX_P19652
    UniProt: P19652

  • Chr Location
    9q32; chr9:114329789-114333256 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061540 Ensembl Gene Model | MGI Sequence Detail 3430 C57BL/6J ±  kb
transcript ENSMUST00000075341 Ensembl | MGI Sequence Detail 775 Not Applicable  
polypeptide ENSMUSP00000074810 Ensembl | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001500 Alpha-1-acid glycoprotein
    IPR012674 Calycin
    IPR000566 Lipocalin/cytosolic fatty-acid binding domain
Molecular
Reagents
less
  • All nucleic 10
    Genomic 3
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13049, MGD-MRK-13052
References
more
  • Summaries
    All 38
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:7384 Baumann H, et al., The acute phase response of mouse liver. Genetic analysis of the major acute phase reactants. J Biol Chem. 1984 Jan 10;259(1):566-73
  • Latest
    J:313767 Watanabe H, et al., An acute phase protein alpha1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action. Sci Rep. 2021 Apr 12;11(1):7953

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory