Septin2 MGI Mouse Gene Detail - MGI:97298

Symbol

Septin2
Name

septin 2
Synonyms

mKIAA0158, Nedd5, Sept2

Feature Type

protein coding gene
IDs

MGI:97298
NCBI Gene: 18000
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:93406238-93437455 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.24 cM
Mapping Data

1 experiment

SNPs within 2kb

540 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97298	protein coding gene	Chr1:93406238-93437982 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016343	protein coding gene	Chr1:95104869-95137109 (+)
A/J	MGP_AJ_G0016324	protein coding gene	Chr1:91697044-91726797 (+)
AKR/J	MGP_AKRJ_G0016285	protein coding gene	Chr1:94407611-94437808 (+)
BALB/cJ	MGP_BALBcJ_G0016280	protein coding gene	Chr1:91881094-91912729 (+)
C3H/HeJ	MGP_C3HHeJ_G0016109	protein coding gene	Chr1:94660835-94691528 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016739	protein coding gene	Chr1:98719909-98752103 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014457	protein coding gene	Chr1:85952381-85984167 (+)
CAST/EiJ	MGP_CASTEiJ_G0015692	protein coding gene	Chr1:93991555-94023022 (+)
CBA/J	MGP_CBAJ_G0016083	protein coding gene	Chr1:101912762-101947924 (+)
DBA/2J	MGP_DBA2J_G0016188	protein coding gene	Chr1:90893416-90923632 (+)
FVB/NJ	MGP_FVBNJ_G0016187	protein coding gene	Chr1:89969264-90000037 (+)
LP/J	MGP_LPJ_G0016259	protein coding gene	Chr1:96284005-96315662 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016212	protein coding gene	Chr1:105019404-105053381 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016778	protein coding gene	Chr1:94421955-94454287 (+)
PWK/PhJ	MGP_PWKPhJ_G0015477	protein coding gene	Chr1:90332924-90363409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015261	protein coding gene	Chr1:93370345-93406366 (+)
WSB/EiJ	MGP_WSBEiJ_G0015752	protein coding gene	Chr1:94240983-94274194 (+)

Human Ortholog

SEPTIN2, septin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEPTIN2, septin 2
Synonyms

DIFF6, hNedd5, NEDD-5, NEDD5, Pnutl3, SEPT2, Septin-2
Links

HGNC:7729

NCBI Gene ID: 4735

UniProt: Q15019
Chr Location

2q37.3; chr2:241315100-241354027 (+) GRCh38

MGI Vertebrate Homology

Septin2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEPTIN2
Protein SuperFamily

Septin
Gene Tree

Septin2

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

46
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Septin2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

42
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

54
Tissues

18
cDNA Data

248
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase septin2

ZFIN septin2

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All Sequences

97
RefSeq

26
UniProt

10
CCDS

CCDS15190.1, CCDS48328.1

Ensembl

ENSMUSG00000026276 (Evidence)
NCBI Gene

18000

			Length	Strain/Species	Flank
genomic	18000	NCBI Gene Model \| MGI Sequence Detail	31218	C57BL/6J	± kb
transcript	NM_001421499	RefSeq \| MGI Sequence Detail	3385	C57BL/6
polypeptide	P42208	UniProt \| EBI \| MGI Sequence Detail	361	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000014654 septin-2

(term hierarchy)
PDB

3FTQ
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR016491 Septin

IPR008113 Septin 2

IPR030379 Septin-type guanine nucleotide-binding (G) domain
GlyGen

P42208 1 site, 1 O-linked glycan (1 site)

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All nucleic 251

cDNA 248

Primer pair 3

Microarray probesets 4

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MGD-MRK-12811, MGI:2138573, MGI:6368831

Summaries

All 61

Developmental Gene Expression 11

Gene Ontology 8

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:339068 Martens AK, et al., Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice. Cytoskeleton (Hoboken). 2022 Nov 15;

TSS for Septin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8175	Chr1:93406230-93406255 (+)	5 bp
Tssr8176	Chr1:93406703-93406776 (+)	502 bp
Tssr8177	Chr1:93406790-93406795 (+)	555 bp
Tssr8178	Chr1:93406809-93406820 (+)	577 bp
Tssr8179	Chr1:93406920-93406956 (+)	700 bp
Tssr8180	Chr1:93410316-93410322 (+)	4,081 bp
Tssr165	Chr1:93417654-93417656 (+)	11,417 bp
Tssr8181	Chr1:93429290-93429303 (+)	23,059 bp
Tssr8182	Chr1:93435602-93435617 (+)	29,372 bp
Tssr8183	Chr1:93436847-93436879 (+)	30,625 bp
Tssr8184	Chr1:93436884-93436901 (+)	30,655 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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