Mrc1 Gene Detail

Summary

• Symbol
  Mrc1
• Name
  mannose receptor, C type 1
• Synonyms
  CD206, MR

• Feature Type
  protein coding gene
• IDs
  MGI:97142
  NCBI Gene: 17533
• Alliance
  gene page
• Transcription Start Sites
  35 TSS
• Candidate for QTL
  2 QTL

Location &
Maps

• Sequence Map
  Chr2:14234225-14336834 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 10.46 cM
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  322 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97142	protein coding gene	Chr2:14234203-14336868 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025362	protein coding gene	Chr2:11738659-11848506 (+)
A/J	MGP_AJ_G0025339	protein coding gene	Chr2:11309466-11414025 (+)
AKR/J	MGP_AKRJ_G0025308	protein coding gene	Chr2:11643537-11751116 (+)
BALB/cJ	MGP_BALBcJ_G0025335	protein coding gene	Chr2:11304507-11409556 (+)
C3H/HeJ	MGP_C3HHeJ_G0025095	protein coding gene	Chr2:11579840-11696735 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025777	protein coding gene	Chr2:12060782-12152451 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023192	protein coding gene	Chr2:10860535-10946678 (+)
CAST/EiJ	MGP_CASTEiJ_G0024558	protein coding gene	Chr2:11558651-11657980 (+)
CBA/J	MGP_CBAJ_G0025074	protein coding gene	Chr2:12578324-12706116 (+)
DBA/2J	MGP_DBA2J_G0025206	protein coding gene	Chr2:11196581-11317098 (+)
FVB/NJ	MGP_FVBNJ_G0025168	protein coding gene	Chr2:11098366-11188586 (+)
LP/J	MGP_LPJ_G0025292	protein coding gene	Chr2:11667002-11780403 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025200	protein coding gene	Chr2:12410692-12526501 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025835	protein coding gene	Chr2:11547286-11662599 (+)
PWK/PhJ	MGP_PWKPhJ_G0024309	protein coding gene	Chr2:11070797-11160173 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024109	protein coding gene	Chr2:11609052-11712971 (+)
WSB/EiJ	MGP_WSBEiJ_G0024628	protein coding gene	Chr2:11683680-11786732 (+)

Homology

• Human Ortholog
  MRC1, mannose receptor C-type 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MRC1, mannose receptor C-type 1
  
• Synonyms
  bA541I19.1, CD206, CLEC13D, CLEC13DL, hMR, MMR, MRC1L1
• Links
  HGNC:7228

  NCBI Gene ID: 4360

  neXtProt AC: NX_P22897

  UniProt: P22897

  
  
• Chr Location
  10p12.33; chr10:17809348-17911164 (+)  GRCh38

---

• MGI Vertebrate Homology
  Mrc1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: MRC1
• Gene Tree
  Mrc1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 2 alleles in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  55 phenotype references
  

• All Mutations and Alleles
  9
• Endonuclease-mediated
  5
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  85 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Male homozygotes for one targeted null mutation die in utero. Heterozygous females clear lutropin from the circulation more slowly and have smaller litters due to reduced implantation. Another targeted knockout is viable and homozygotes are less susceptible to parasitic infection.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  18
• GO References
  6

Expression

• Assay Results
  795
• Tissues
  64
• cDNA Data
  32
• Literature Summary
  34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mrc1
  ZFIN mrc1a, mrc1b

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS15700.1

• Ensembl
  ENSMUSG00000026712 (Evidence)
• NCBI Gene
  17533

Representative Sequences			Length	Strain/Species
genomic	17533	NCBI Gene Model | MGI Sequence Detail	102610	C57BL/6J
transcript	NM_008625	RefSeq | MGI Sequence Detail	5322	ZRU/MplStud
polypeptide	Q61830	UniProt | EBI | MGI Sequence Detail	1456	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000002972 macrophage mannose receptor 1
  (term hierarchy)
• PDB
  1DQG, 1DQO, 1FWU, 1FWV
• InterPro Domains
  IPR018378 C-type lectin, conserved site
  IPR016187 C-type lectin fold
  IPR001304 C-type lectin-like
  IPR016186 C-type lectin-like/link domain superfamily
  IPR000562 Fibronectin type II domain
  IPR036943 Fibronectin type II domain superfamily
  IPR013806 Kringle-like fold
  IPR000772 Ricin B, lectin domain
  IPR035992 Ricin B-like lectins

Molecular
Reagents

• All nucleic 34

  Genomic 1

  cDNA 32

  Other 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-12537, MGI:2139335

References

• Summaries
  All 126

  Developmental Gene Expression 34

  Gene Ontology 6

  Phenotypes 55
• Earliest
  J:3309 Harris N, et al., Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the level of transcription. Blood. 1992 Nov 1;80(9):2363-73
• Latest
  J:343278 Subileau M, et al., Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):7

TSS for Mrc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16233	Chr2:14234201-14234215 (+)	-17 bp
Tssr16234	Chr2:14252354-14252375 (+)	18,140 bp
Tssr16235	Chr2:14263431-14263475 (+)	29,228 bp
Tssr16236	Chr2:14265987-14266037 (+)	31,787 bp
Tssr16237	Chr2:14268119-14268132 (+)	33,901 bp
Tssr16238	Chr2:14268205-14268220 (+)	33,988 bp
Tssr16239	Chr2:14271308-14271320 (+)	37,089 bp
Tssr16240	Chr2:14276509-14276520 (+)	42,290 bp
Tssr16241	Chr2:14278273-14278277 (+)	44,050 bp
Tssr16242	Chr2:14278315-14278344 (+)	44,105 bp
Tssr16243	Chr2:14278394-14278399 (+)	44,172 bp
Tssr16244	Chr2:14281089-14281099 (+)	46,869 bp
Tssr16245	Chr2:14281107-14281128 (+)	46,893 bp
Tssr16246	Chr2:14283732-14283737 (+)	49,510 bp
Tssr16247	Chr2:14284387-14284396 (+)	50,167 bp
Tssr16248	Chr2:14286953-14287001 (+)	52,752 bp
Tssr16249	Chr2:14293895-14293915 (+)	59,680 bp
Tssr16250	Chr2:14293960-14293971 (+)	59,741 bp
Tssr16251	Chr2:14298314-14298325 (+)	64,095 bp
Tssr16252	Chr2:14299624-14299637 (+)	65,406 bp
Tssr16253	Chr2:14299673-14299691 (+)	65,457 bp
Tssr16254	Chr2:14310144-14310165 (+)	75,930 bp
Tssr16255	Chr2:14311847-14311850 (+)	77,624 bp
Tssr16256	Chr2:14315710-14315716 (+)	81,488 bp
Tssr16257	Chr2:14319091-14319111 (+)	84,876 bp
Tssr16258	Chr2:14319239-14319260 (+)	85,025 bp
Tssr16259	Chr2:14320159-14320172 (+)	85,941 bp
Tssr16260	Chr2:14320991-14321004 (+)	86,773 bp
Tssr16261	Chr2:14335874-14335892 (+)	101,658 bp
Tssr16262	Chr2:14335920-14335942 (+)	101,706 bp
Tssr16263	Chr2:14335946-14336007 (+)	101,752 bp
Tssr16264	Chr2:14336182-14336193 (+)	101,963 bp
Tssr16265	Chr2:14336240-14336262 (+)	102,026 bp
Tssr16266	Chr2:14336267-14336291 (+)	102,054 bp
Tssr16267	Chr2:14336307-14336329 (+)	102,093 bp

Mrc1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Abhr1	Chr2, syntenic		J:122917	The present study fine maps two previously identified airway hyper-responsiveness QTLs on mouse Chromosome 2 named Abhr1 (10 cM) and Abhr2 (30 cM). Thirty-seven polymorphic chromosome 2 markers were genotyped in 450 (C3H/HeJ x A/J)F1 x A/J backcross animals. Mrc1 at 5 cM was identified as a potential candidate gene for Abhr1. Ptgs1 at 29 cM was identified as a potential candidate gene for Abhr2. Sequence analysis of Mrc1 and Ptgs1 sequences did not detect polymorphism between A/J and C3H/HeJ. Gene expression analysis of Mrc1 and Ptgs1 lung mRNA following induction of allergic asthma in A/J and C3H/HeJ animals was performed. Ptgs1 was found to be downregulated in both inbred strains 72 hours after allergic asthma induction; however a strain-specific expression difference was not detected.
Abhr2	Chr2, 22.83 cM		J:122917	The present study fine maps two previously identified airway hyper-responsiveness QTLs on mouse Chromosome 2 named Abhr1 (10 cM) and Abhr2 (30 cM). Thirty-seven polymorphic chromosome 2 markers were genotyped in 450 (C3H/HeJ x A/J)F1 x A/J backcross animals. Mrc1 at 5 cM was identified as a potential candidate gene for Abhr1. Ptgs1 at 29 cM was identified as a potential candidate gene for Abhr2. Sequence analysis of Mrc1 and Ptgs1 sequences did not detect polymorphism between A/J and C3H/HeJ. Gene expression analysis of Mrc1 and Ptgs1 lung mRNA following induction of allergic asthma in A/J and C3H/HeJ animals was performed. Ptgs1 was found to be downregulated in both inbred strains 72 hours after allergic asthma induction; however a strain-specific expression difference was not detected.

*cM position of peak correlated region/marker