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Kitl Gene Detail
Summary
  • Symbol
    Kitl
  • Name
    kit ligand
  • Synonyms
    blz, Gb, grizzle-belly, Kitlg, Mgf, SCF, SF, Sl, SLF, Steel, Steel factor, stem cell factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96974
    NCBI Gene: 17311
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:99851492-99936278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 51.40 cM
  • Mapping Data
    52 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1120 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96974
 protein coding gene Chr10:99851477-99936278 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017689
 protein coding gene Chr10:101871849-101963601 (+)
A/J MGP_AJ_G0017668
 protein coding gene Chr10:98165569-98251097 (+)
AKR/J MGP_AKRJ_G0017628
 protein coding gene Chr10:100965612-101054692 (+)
BALB/cJ MGP_BALBcJ_G0017632
 protein coding gene Chr10:98476803-98565626 (+)
C3H/HeJ MGP_C3HHeJ_G0017455
 protein coding gene Chr10:100997089-101085542 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018088
 protein coding gene Chr10:105404476-105502604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015768
 protein coding gene Chr10:93575706-93662258 (+)
CAST/EiJ MGP_CASTEiJ_G0017018
 protein coding gene Chr10:101105167-101205619 (+)
CBA/J MGP_CBAJ_G0017424
 protein coding gene Chr10:109481447-109582800 (+)
DBA/2J MGP_DBA2J_G0017530
 protein coding gene Chr10:97256881-97342991 (+)
FVB/NJ MGP_FVBNJ_G0017523
 protein coding gene Chr10:96461120-96547674 (+)
LP/J MGP_LPJ_G0017604
 protein coding gene Chr10:102460705-102562922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017553
 protein coding gene Chr10:110756939-110847279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018126
 protein coding gene Chr10:100939138-101032261 (+)
PWK/PhJ MGP_PWKPhJ_G0016800
 protein coding gene Chr10:97387232-97473857 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016589
 protein coding gene Chr10:99810517-99905138 (+)
WSB/EiJ MGP_WSBEiJ_G0017078
 protein coding gene Chr10:100944334-101031327 (+)



Homology
more
  • Human Ortholog
    KITLG, KIT ligand
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KITLG, KIT ligand
  • Synonyms
    DCUA, DFNA69, FPH2, FPHH, Kitl, KL-1, MGF, SCF, SF, SHEP7, SLF, WS2F
  • Links
    NCBI Gene ID: 4254
    neXtProt AC: NX_P21583
    UniProt: P21583

  • Chr Location
    12q21.32; chr12:88492793-88580851 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human KITLG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 54 alleles in 49 genetic backgrounds
    90 phenotypes from multigenic genotypes
    10 images
    232 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene affect migration of embryonic stem cells and cause similar phenotypes to mutations in its receptor gene (Kit). Mutants show mild to severe defects in pigmentation, hemopoiesis and reproduction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1412
  • Tissues
    382
  • cDNA Data
    112
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019966 Ensembl Gene Model | MGI Sequence Detail 84787 C57BL/6J ±  kb
    transcript ENSMUST00000105283 Ensembl | MGI Sequence Detail 5648 Not Applicable  
    polypeptide ENSMUSP00000100920 Ensembl | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 156
      Genomic 12
      cDNA 118
      Primer pair 18
      Other 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10006, MGD-MRK-12219, MGD-MRK-14435, MGD-MRK-2018, MGD-MRK-2093, MGI:5304521
    References
    more
    • Summaries
      All 573
      Developmental Gene Expression 121
      Diseases 1
      Gene Ontology 21
      Phenotypes 232
    • Earliest
      J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse: With effects on coat pigment and blood. J Hered. 1956;47(3):123-128
    • Latest
      J:338829 Lee J, et al., Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development. Sci Rep. 2023 Jul 29;13(1):12309
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/19/2023
    MGI 6.22     		The Jackson Laboratory