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Mest Gene Detail
Summary
  • Symbol
    Mest
  • Name
    mesoderm specific transcript
  • Synonyms
    Peg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96968
    NCBI Gene: 17294
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30723546-30748464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.53 cM, cytoband B1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    26
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96968
 protein coding gene Chr6:30723546-30783580 (+)
129S1/SvImJ ENSMUSG00200033325
 protein coding gene Chr6:27784120-27784302 (+)
129S1/SvImJ ENSMUSGG00200054832
 protein coding gene Chr6:27785042-27813206 (+)
A/J ENSMUSG00195007563
 protein coding gene Chr6:27746754-27746936 (+)
A/J ENSMUSGG00195055196
 protein coding gene Chr6:27747676-27775840 (+)
AKR/J ENSMUSG00220002760
 protein coding gene Chr6:27339837-27340019 (+)
AKR/J ENSMUSGG00220054852
 protein coding gene Chr6:27340759-27368925 (+)
BALB/cJ ENSMUSGG00180055397
 protein coding gene Chr6:27879319-27907481 (+)
BALB/cJ ENSMUSG00180020690
 protein coding gene Chr6:27878397-27878579 (+)
C3H/HeJ ENSMUSG00175018882
 protein coding gene Chr6:27741560-27741742 (+)
C3H/HeJ ENSMUSGG00175054588
 protein coding gene Chr6:27742482-27770638 (+)
C57BL/6NJ ENSMUSG00215021691
 protein coding gene Chr6:27784958-27785140 (+)
C57BL/6NJ ENSMUSGG00215055670
 protein coding gene Chr6:27785880-27814041 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028192
 protein coding gene Chr6:25587210-25612667 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055051
 protein coding gene Chr6:27763641-27791800 (+)
CBA/J ENSMUSG00210003413
 protein coding gene Chr6:27762719-27762901 (+)
DBA/2J ENSMUSGG00185057724
 protein coding gene Chr6:27858198-27886366 (+)
DBA/2J ENSMUSG00185020325
 protein coding gene Chr6:27857276-27857458 (+)
FVB/NJ ENSMUSGG00205054560
 protein coding gene Chr6:27832756-27860919 (+)
FVB/NJ ENSMUSG00205018763
 protein coding gene Chr6:27831834-27832016 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055597
 protein coding gene Chr6:28801578-28829737 (+)
LP/J ENSMUSG00230029291
 protein coding gene Chr6:28800656-28800838 (+)
NOD/ShiLtJ ENSMUSGG00190054942
 protein coding gene Chr6:27627274-27655431 (+)
NOD/ShiLtJ ENSMUSG00190021243
 protein coding gene Chr6:27626352-27626534 (+)
NZO/HlLtJ ENSMUSG00225013920
 protein coding gene Chr6:30761667-30761849 (+)
NZO/HlLtJ ENSMUSGG00225055469
 protein coding gene Chr6:30762589-30790748 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MEST, mesoderm specific transcript
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEST, mesoderm specific transcript
  • Synonyms
    PEG1
  • Links
    NCBI Gene ID: 4232
    UniProt: Q5EB52

  • Chr Location
    7q32.2; chr7:130486171-130506465 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mest mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retardation of embryonic growth and subtle cardiac abnormalities associated with reduced postnatal survival rates. Mutant females exhibit abnormal maternal behavior and impaired placentophagia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    209
  • cDNA Data
    29
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051855 Ensembl Gene Model | MGI Sequence Detail 24919 C57BL/6J ±  kb
    transcript ENSMUST00000124665 Ensembl | MGI Sequence Detail 2665 Not Applicable  
    polypeptide ENSMUSP00000117713 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 7
      cDNA 33
      Primer pair 15
      Other 6
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12202, MGI:1353588, MGI:2141362
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 87
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:16422 Sado T, et al., A novel Mesoderm-Specific cDNA isolated from a mouse embryonal carcinoma cell line. Dev Growth Differ. 1993 Oct;35(5):551-60
    • Latest
      J:381083 Hanin G, et al., ZFP57 is a regulator of postnatal growth and life-long health. Nat Commun. 2026 Jan 27;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory