Lamb1 MGI Mouse Gene Detail - MGI:96743

Symbol

Lamb1
Name

laminin B1
Synonyms

C80098, C81607, D130003D08Rik, Lamb-1

Feature Type

protein coding gene
IDs

MGI:96743
NCBI Gene: 16777
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:31315233-31379643 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.39 cM
Mapping Data

25 experiments

SNPs within 2kb

2078 from dbSNP Build 142
Strain Annotations

19
PCR

2
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96743	protein coding gene	Chr12:31315230-31379643 (+)
129S1/SvImJ	ENSMUSG00200014865	protein coding gene	Chr12:23120025-23184495 (+)
A/J	ENSMUSG00195021977	protein coding gene	Chr12:25794857-25859356 (+)
AKR/J	ENSMUSG00220028675	protein coding gene	Chr12:23763367-23827859 (+)
BALB/cJ	ENSMUSG00180023633	protein coding gene	Chr12:24794005-24858502 (+)
C3H/HeJ	ENSMUSG00175020958	protein coding gene	Chr12:27827420-27891911 (+)
C57BL/6NJ	ENSMUSG00215015347	protein coding gene	Chr12:24240931-24305360 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017674	protein coding gene	Chr12:27676065-27742108 (+)
CAST/EiJ	ENSTCUG00005009592	protein coding gene	Chr12:24599988-24664753 (+)
CBA/J	ENSMUSG00210007616	protein coding gene	Chr12:24316736-24381231 (+)
DBA/2J	ENSMUSG00185014334	protein coding gene	Chr12:26354086-26418510 (+)
FVB/NJ	ENSMUSG00205006149	protein coding gene	Chr12:24385465-24449888 (+)
JF1/MsJ	ENSUMUG00000009700	protein coding gene	Chr12:30530853-30595772 (+)
LP/J	ENSMUSG00230021170	protein coding gene	Chr12:33314203-33378621 (+)
NOD/ShiLtJ	ENSMUSG00190017472	protein coding gene	Chr12:23290767-23355189 (+)
NZO/HlLtJ	ENSMUSG00225030335	protein coding gene	Chr12:35508979-35573400 (+)
PWK/PhJ	ENSLUMG00010010950	protein coding gene	Chr12:24767904-24832410 (+)
SPRET/EiJ	ENSMSPG00010005827	protein coding gene	Chr12:25265825-25330553 (+)
WSB/EiJ	ENSIUOG00005019258	protein coding gene	Chr12:24003208-24067701 (+)

Human Ortholog

LAMB1, laminin subunit beta 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMB1, laminin subunit beta 1
Synonyms

CLM, LIS5, LKBMH, LUCAO
Links

HGNC:6486

NCBI Gene ID: 3912

UniProt: P07942
Chr Location

7q31.1; chr7:107923715-108004434 (-) GRCh38

MGI Vertebrate Homology

Lamb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LAMB1
Gene Tree

Lamb1

Diseases

2 with human LAMB1 associations

				Human Disease	Mouse Models
				autistic disorder IDs autistic disorder DOID:12849 EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 ORDO:106 UMLS_CUI:C0004352
				leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus IDs leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus DOID:0112230 OMIM:615191

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

8
Gene trapped

17
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

86 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. Mice heterozygous for a spontaneous mutation exhibit dystonis with impaired neuron firing.

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All GO Annotations

89
GO References

40

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1205
Tissues

299
cDNA Data

27
Literature Summary

115

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LAMB1

Xenbase lamb1

ZFIN lamb1a

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All Sequences

70
RefSeq

4
UniProt

10
CCDS

CCDS25862.2

Ensembl

ENSMUSG00000002900 (Evidence)
NCBI Gene

16777

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002900	Ensembl Gene Model \| MGI Sequence Detail	64411	C57BL/6J	± kb
transcript	ENSMUST00000239496	Ensembl \| MGI Sequence Detail	5778	Not Applicable
polypeptide	ENSMUSP00000159366	Ensembl \| MGI Sequence Detail	1834	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000029583 laminin subunit beta-1

(term hierarchy)
PDB

4AQS, 5MC9
InterPro Domains

IPR000742 EGF-like domain

IPR056558 LAMB1/2/3/4, helical domain

IPR056863 Laminin/attractin/netrin-like, EGF domain

IPR013015 Laminin IV type B

IPR050440 Laminin/Netrin Extracellular Matrix

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain
GlyGen

P02469 14 sites, 9 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

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All nucleic 48

Genomic 1

cDNA 30

Primer pair 10

Other 7

Antibodies 18

Microarray probesets 7

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MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114

Summaries

All 247

Developmental Gene Expression 115

Gene Ontology 40

Phenotypes 19
Earliest

J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
Latest

J:382729 Goodwin K, et al., Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo. Sci Adv. 2026 Mar 20;12(12):eaec7919

TSS for Lamb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113105	Chr12:31314264-31314289 (+)	-956 bp
Tssr113106	Chr12:31314986-31315001 (+)	-239 bp
Tssr113107	Chr12:31315240-31315266 (+)	20 bp
Tssr113108	Chr12:31315278-31315321 (+)	67 bp
Tssr113109	Chr12:31315454-31315465 (+)	227 bp
Tssr113110	Chr12:31315471-31315483 (+)	244 bp
Tssr113111	Chr12:31316261-31316308 (+)	1,052 bp
Tssr113112	Chr12:31316311-31316337 (+)	1,091 bp
Tssr113113	Chr12:31320238-31320241 (+)	5,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24