Hikeshi MGI Mouse Gene Detail - MGI:96738 - heat shock protein nuclear import factor

Symbol

Hikeshi
Name

heat shock protein nuclear import factor
Synonyms

0610007P06Rik, 1110002N09Rik, Hikeshi, l(7)6Rn, l7Rn6

Feature Type

protein coding gene
IDs

MGI:96738
NCBI Gene: 67669
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:89567893-89590446 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 50.40 cM, cytoband E1
Mapping Data

5 experiments

SNPs within 2kb

143 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96738	protein coding gene	Chr7:89566737-89590446 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032500	protein coding gene	Chr7:92308391-92341255 (-)
A/J	MGP_AJ_G0032474	protein coding gene	Chr7:90095143-90121639 (-)
AKR/J	MGP_AKRJ_G0032410	protein coding gene	Chr7:92186765-92216796 (-)
BALB/cJ	MGP_BALBcJ_G0032485	protein coding gene	Chr7:89736526-89767814 (-)
C3H/HeJ	MGP_C3HHeJ_G0032200	protein coding gene	Chr7:92585341-92614051 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032983	protein coding gene	Chr7:95905474-95931042 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029978	protein coding gene	Chr7:92995797-93018421 (-)
CAST/EiJ	MGP_CASTEiJ_G0031527	protein coding gene	Chr7:84024478-84053484 (-)
CBA/J	MGP_CBAJ_G0032167	protein coding gene	Chr7:99101561-99130198 (-)
DBA/2J	MGP_DBA2J_G0032319	protein coding gene	Chr7:88521413-88546743 (-)
FVB/NJ	MGP_FVBNJ_G0032275	protein coding gene	Chr7:88394965-88417190 (-)
LP/J	MGP_LPJ_G0032408	protein coding gene	Chr7:93553599-93580071 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032309	protein coding gene	Chr7:100110105-100136951 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033005	protein coding gene	Chr7:91482506-91507999 (-)
PWK/PhJ	MGP_PWKPhJ_G0031245	protein coding gene	Chr7:81554367-81582233 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031088	protein coding gene	Chr7:78805960-78831335 (-)
WSB/EiJ	MGP_WSBEiJ_G0031644	protein coding gene	Chr7:92140090-92166908 (-)

Human Ortholog

HIKESHI, heat shock protein nuclear import factor hikeshi

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HIKESHI, heat shock protein nuclear import factor hikeshi
Synonyms

C11orf73, HLD13, HSPC138, HSPC179, L7RN6, OPI10
Links

HGNC:26938

NCBI Gene ID: 51501

neXtProt AC: NX_Q53FT3

UniProt: Q53FT3
Chr Location

11q14.2; chr11:86302211-86345943 (+) GRCh38

MGI Vertebrate Homology

Hikeshi stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HIKESHI
Gene Tree

Hikeshi

Diseases

1 with human HIKESHI associations

				Human Disease	Mouse Models
				hypomyelinating leukodystrophy 13 IDs hypomyelinating leukodystrophy 13 DOID:0060795 OMIM:616881

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

57
Radiation induced

3
Targeted

1
Genomic Mutations

4 involving Hikeshi
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced mutation die prenatally or neonatally, and exhibit cyanoisis with a significant emphysematous phenotype at birth. The secretory apparatus in Clara cells is also affected.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

21
cDNA Data

63
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hikeshi

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All Sequences

74
RefSeq

16
UniProt

5
CCDS

CCDS21445.1, CCDS80747.1, CCDS80748.1

Ensembl

ENSMUSG00000062797 (Evidence)
NCBI Gene

67669

			Length	Strain/Species	Flank
genomic	67669	NCBI Gene Model \| MGI Sequence Detail	22554	C57BL/6J	± kb
transcript	NR_111916	RefSeq \| MGI Sequence Detail	2579	ZRU/MplStud
polypeptide	Q9DD02	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000039135 protein Hikeshi

(term hierarchy)
InterPro Domains

IPR048364 Hikeshi-like, C-terminal domain

IPR008493 Hikeshi-like, N-terminal domain

IPR031318 OPI10 family

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All nucleic 71

Genomic 2

cDNA 63

Primer pair 1

Other 5

Microarray probesets 3

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MGD-MRK-11694, MGD-MRK-11726, MGI:1913365, MGI:1914919

Summaries

All 61

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 37
Earliest

J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
Latest

J:342318 Li L, et al., Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination. Dev Cell. 2023 Nov 6;58(21):2275-2291.e6

TSS for Hikeshi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73503	Chr7:89590428-89590431 (-)	16 bp
Tssr73502	Chr7:89590404-89590421 (-)	33 bp
Tssr73501	Chr7:89590344-89590382 (-)	83 bp
Tssr73500	Chr7:89590275-89590278 (-)	169 bp
Tssr73499	Chr7:89590250-89590261 (-)	190 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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