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Itih2 Gene Detail
Summary
  • Symbol
    Itih2
  • Name
    inter-alpha trypsin inhibitor, heavy chain 2
  • Synonyms
    Intin2, Itih-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96619
    NCBI Gene: 16425
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:10099408-10135492 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 6.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1225 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96619
 protein coding gene Chr2:10099404-10136207 (-)
129S1/SvImJ ENSMUSG00200028124
 protein coding gene Chr2:6949959-6986771 (-)
A/J ENSMUSG00195015855
 protein coding gene Chr2:7090535-7127354 (-)
AKR/J ENSMUSG00220005457
 protein coding gene Chr2:7065970-7102775 (-)
BALB/cJ ENSMUSG00180030621
 protein coding gene Chr2:7168492-7205302 (-)
C3H/HeJ ENSMUSG00175015278
 protein coding gene Chr2:7075251-7112060 (-)
C57BL/6NJ ENSMUSG00215009756
 protein coding gene Chr2:7189029-7225836 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023168
 protein coding gene Chr2:6626909-6662442 (-)
CAST/EiJ ENSTCUG00005004440
 protein coding gene Chr2:6989869-7026016 (-)
CBA/J ENSMUSG00210026819
 protein coding gene Chr2:7102274-7139088 (-)
DBA/2J ENSMUSG00185012459
 protein coding gene Chr2:7055184-7091986 (-)
FVB/NJ ENSMUSG00205023458
 protein coding gene Chr2:7042190-7078588 (-)
JF1/MsJ ENSUMUG00000002056
 protein coding gene Chr2:7025614-7061643 (-)
LP/J ENSMUSG00230002652
 protein coding gene Chr2:9000761-9037565 (-)
NOD/ShiLtJ ENSMUSG00190005634
 protein coding gene Chr2:7070153-7106957 (-)
NZO/HlLtJ ENSMUSG00225001282
 protein coding gene Chr2:16740189-16776991 (-)
PWK/PhJ ENSLUMG00010027248
 protein coding gene Chr2:7134419-7170591 (-)
SPRET/EiJ ENSMSPG00010024687
 protein coding gene Chr2:7193778-7230813 (-)
WSB/EiJ ENSIUOG00005022155
 protein coding gene Chr2:7114696-7151104 (-)



Homology
more
  • Human Ortholog
    ITIH2, inter-alpha-trypsin inhibitor heavy chain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITIH2, inter-alpha-trypsin inhibitor heavy chain 2
  • Synonyms
    H2P, ITI-HC2, SHAP
  • Links
    NCBI Gene ID: 3698
    UniProt: P19823

  • Chr Location
    10p14; chr10:7699386-7758675 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    689
  • Tissues
    21
  • cDNA Data
    62
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16425 NCBI Gene Model | MGI Sequence Detail 36085 C57BL/6J ±  kb
transcript NM_010582 RefSeq | MGI Sequence Detail 3114 ZRU/MplStud  
polypeptide Q61703 UniProt | EBI | MGI Sequence Detail 946 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009147 inter-alpha-trypsin inhibitor heavy chain H2
    (term hierarchy)
  • InterPro Domains
    IPR050934 Inter-alpha-trypsin inhibitor heavy chain
    IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
    IPR013694 VIT domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q61703 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 67
    cDNA 65
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11435, MGD-MRK-11498, MGD-MRK-11501, MGI:2139047
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory