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Inhbb Gene Detail
Summary
  • Symbol
    Inhbb
  • Name
    inhibin beta-B
  • Synonyms
    activin beta-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:96571
    NCBI Gene: 16324
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:119343195-119349978 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96571
 protein coding gene Chr1:119343193-119349978 (-)
129S1/SvImJ ENSMUSG00200001606
 protein coding gene Chr1:116820211-116826995 (-)
A/J ENSMUSG00195004517
 protein coding gene Chr1:116060957-116067748 (-)
AKR/J ENSMUSG00220023914
 protein coding gene Chr1:115874114-115880909 (-)
BALB/cJ ENSMUSG00180011844
 protein coding gene Chr1:116466061-116472851 (-)
C3H/HeJ ENSMUSG00175019259
 protein coding gene Chr1:116291870-116298658 (-)
C57BL/6NJ ENSMUSG00215009733
 protein coding gene Chr1:116250295-116257080 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014511
 protein coding gene Chr1:111455427-111462080 (-)
CAST/EiJ ENSTCUG00005006436
 protein coding gene Chr1:115214096-115220888 (-)
CBA/J ENSMUSG00210001236
 protein coding gene Chr1:116121516-116128302 (-)
DBA/2J ENSMUSG00185013608
 protein coding gene Chr1:120569820-120576609 (-)
FVB/NJ ENSMUSG00205010492
 protein coding gene Chr1:115619290-115626078 (-)
JF1/MsJ ENSUMUG00000023314
 protein coding gene Chr1:119674481-119681301 (-)
LP/J ENSMUSG00230008486
 protein coding gene Chr1:119998040-120004824 (-)
NOD/ShiLtJ ENSMUSG00190005943
 protein coding gene Chr1:116106692-116113480 (-)
NZO/HlLtJ ENSMUSG00225004321
 protein coding gene Chr1:123788806-123795603 (-)
PWK/PhJ ENSLUMG00010014428
 protein coding gene Chr1:115252881-115259675 (-)
SPRET/EiJ ENSMSPG00010015870
 protein coding gene Chr1:117881852-117888635 (-)
WSB/EiJ ENSIUOG00005002795
 protein coding gene Chr1:115969959-115976759 (-)



Homology
more
  • Human Ortholog
    INHBB, inhibin subunit beta B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBB, inhibin subunit beta B
  • Links
    NCBI Gene ID: 3625
    UniProt: P09529

  • Chr Location
    2q14.2; chr2:120346136-120351803 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygotes for targeted null mutations exhibit open eyes at birth and impaired maternal nuturing. Mutant females for one line exhibit extended gestation length, retarded mammary duct elongation and alveolar morphogenesis, and are unable to nurse their pups.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    165
  • cDNA Data
    67
  • Literature Summary
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037035 Ensembl Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
    transcript ENSMUST00000038765 Ensembl | MGI Sequence Detail 4255 Not Applicable  
    polypeptide ENSMUSP00000044918 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      Genomic 8
      cDNA 76
      Primer pair 9
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11408
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 58
      Gene Ontology 14
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:370220 Kobayashi N, et al., Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance. Nat Commun. 2025 Apr 17;16(1):3678
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory