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Igh-8 Gene Detail
Summary
  • Symbol
    Igh-8
  • Name
    immunoglobulin heavy chain 8 (heavy chain of IgG3)
  • Feature Type
    gene segment
  • IDs
    MGI:96450
    NCBI Gene: 16021
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:113329416-113330847 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96450
 gene segment Chr12:113329416-113330847 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 5 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display poor T-cell independent immune responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    46
  • Tissues
    45
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    Sequences &
    Gene Models
    less
    • All Sequences
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic M64431 GenBank | ENA | DDBJ | MGI Sequence Detail 1434 BALB/c ±  kb
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 20
      cDNA 9
      Primer pair 1
    Other
    Accession IDs
    less
    MGD-MRK-11247
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 6
    • Earliest
      J:12055 Green MC, Genetic nomenclature for the immunoglobulin loci of the mouse. Immunogenetics. 1979;8:89-97
    • Latest
      J:171251 Haddad D, et al., Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J. 2011 Apr 20;30(8):1608-20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory