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Hyal1 Gene Detail
Summary
  • Symbol
    Hyal1
  • Name
    hyaluronoglucosaminidase 1
  • Synonyms
    Hyal-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96298
    NCBI Gene: 15586
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107454149-107458898 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.17 cM, cytoband F1-F2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96298
 protein coding gene Chr9:107454126-107458909 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ ENSMUSG00215022870
 protein coding gene Chr9:104504520-104508488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032651
 protein coding gene Chr9:102903558-102908213 (+)
CAST/EiJ ENSTCUG00005025393
 protein coding gene Chr9:104277106-104281117 (+)
CBA/J ENSMUSG00210031940
 protein coding gene Chr9:104374664-104378632 (+)
DBA/2J ENSMUSG00185033837
 protein coding gene Chr9:104539491-104543458 (+)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000054158
 protein coding gene Chr9:104363656-104367622 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010031969
 protein coding gene Chr9:104322263-104326220 (+)
SPRET/EiJ ENSMSPG00010033739
 protein coding gene Chr9:106151945-106159216 (+)
WSB/EiJ ENSIUOG00005041467
 protein coding gene Chr9:103621346-103625262 (+)



Homology
more
  • Human Ortholog
    HYAL1, hyaluronidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYAL1, hyaluronidase 1
  • Synonyms
    HYAL-1, LUCA1, MPS9, NAT6
  • Links
    NCBI Gene ID: 3373
    UniProt: Q12794

  • Chr Location
    3p21.31; chr3:50299883-50312890 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hyal1 mouse models; 2 with human HYAL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display a progressive osteoarthritis associated with bony outgrowths, early loss of articular cartilage proteoglycans and accumulation of hyaluronan (HA) in the cartilage of knee joints, but show no signs of non-skeletal tissue GAG accumulation or increased serum HA levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    107
  • cDNA Data
    10
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15586 NCBI Gene Model | MGI Sequence Detail 4750 C57BL/6J ±  kb
    transcript NM_008317 RefSeq | MGI Sequence Detail 2995 ZRU/MplStud  
    polypeptide Q91ZJ9 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 11
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11032, MGD-MRK-11033
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:9611 Fiszer-Szafarz B, et al., Hyal-1, a locus determining serum hyaluronidase polymorphism, on chromosome 9 in mice. Somat Cell Mol Genet. 1989 Jan;15(1):79-83
    • Latest
      J:385501 Chen X, et al., Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis. Life Metab. 2025 Oct;4(5):loaf016
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory