Hrc MGI Mouse Gene Detail - MGI:96226 - histidine rich calcium binding protein

Symbol

Hrc
Name

histidine rich calcium binding protein

Feature Type

protein coding gene
IDs

MGI:96226
NCBI Gene: 15464
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:44984714-44988398 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.26 cM
Mapping Data

9 experiments

SNPs within 2kb

38 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96226	protein coding gene	Chr7:44984693-44988398 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032214	protein coding gene	Chr7:45581213-45584903 (+)
A/J	MGP_AJ_G0032193	protein coding gene	Chr7:44720923-44724613 (+)
AKR/J	MGP_AKRJ_G0032129	protein coding gene	Chr7:45947316-45951015 (+)
BALB/cJ	MGP_BALBcJ_G0032205	protein coding gene	Chr7:44709071-44713470 (+)
C3H/HeJ	MGP_C3HHeJ_G0031921	protein coding gene	Chr7:46441319-46445009 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032697	protein coding gene	Chr7:47849535-47853165 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029711	protein coding gene	Chr7:47273013-47276684 (+)
CAST/EiJ	MGP_CASTEiJ_G0031249	protein coding gene	Chr7:37841481-37845167 (+)
CBA/J	MGP_CBAJ_G0031885	protein coding gene	Chr7:49427253-49430928 (+)
DBA/2J	MGP_DBA2J_G0032043	protein coding gene	Chr7:44383906-44387587 (+)
FVB/NJ	MGP_FVBNJ_G0031994	protein coding gene	Chr7:44163166-44167374 (+)
LP/J	MGP_LPJ_G0032121	protein coding gene	Chr7:46287736-46293405 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032031	protein coding gene	Chr7:48133706-48138954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032713	protein coding gene	Chr7:45168176-45171866 (+)
PWK/PhJ	MGP_PWKPhJ_G0030972	protein coding gene	Chr7:37753712-37757467 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030809	protein coding gene	Chr7:33176689-33180408 (+)
WSB/EiJ	MGP_WSBEiJ_G0031366	protein coding gene	Chr7:45660375-45664049 (+)

Human Ortholog

HRC, histidine rich calcium binding protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HRC, histidine rich calcium binding protein
Links

HGNC:5178

NCBI Gene ID: 3270

neXtProt AC: NX_P23327

UniProt: P23327
Chr Location

19q13.33; chr19:49151198-49155396 (-) GRCh38

MGI Vertebrate Homology

Hrc stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HRC
Gene Tree

Hrc

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired weight gain and weight loss around 1 year of age and increased susceptibility to induced cardiac hypertrophy.

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All GO Annotations

19
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

16
cDNA Data

14
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

5
CCDS

CCDS39950.1

Ensembl

ENSMUSG00000038239 (Evidence)
NCBI Gene

15464

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038239	Ensembl Gene Model \| MGI Sequence Detail	3685	C57BL/6J	± kb
transcript	ENSMUST00000085351	Ensembl \| MGI Sequence Detail	2411	Not Applicable
polypeptide	ENSMUSP00000082459	Ensembl \| MGI Sequence Detail	738	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR019552 Histidine-rich calcium-binding

IPR015666 Sarcoplasmic reticulum histidine-rich calcium-binding protein

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All nucleic 18

Genomic 1

cDNA 16

Primer pair 1

Microarray probesets 4

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MGD-MRK-10933

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:11193 Hofmann SL, et al., cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 1991 Apr;9(4):656-69
Latest

J:243733 Tzimas C, et al., Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovasc Res. 2017 Sep 01;113(11):1403-1417

TSS for Hrc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66513	Chr7:44984680-44984721 (+)	-13 bp
Tssr66514	Chr7:44984723-44984734 (+)	15 bp
Tssr66515	Chr7:44985453-44985473 (+)	749 bp
Tssr66516	Chr7:44985574-44985608 (+)	877 bp
Tssr66517	Chr7:44986327-44986367 (+)	1,633 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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