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Hmga1 Gene Detail
Summary
  • Symbol
    Hmga1
  • Name
    high mobility group AT-hook 1
  • Synonyms
    Hmga1a, Hmga1b, Hmgi, Hmgiy, HMG-I(Y), HMGI(Y), HMGY
  • Feature Type
    protein coding gene
  • IDs
    MGI:96160
    NCBI Gene: 15361
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27775471-27782648 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    24
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96160
 protein coding gene Chr17:27774798-27782649 (+)
129S1/SvImJ ENSMUSG00200050995
 protein coding gene Chr11:118017042-118018668 (+)
129S1/SvImJ ENSMUSG00200053536
 protein coding gene Chr17:23437328-23444524 (+)
A/J ENSMUSG00195025560
 protein coding gene Chr11:117692116-117693740 (+)
A/J ENSMUSG00195050777
 protein coding gene Chr17:24252091-24259308 (+)
AKR/J ENSMUSG00220023813
 protein coding gene Chr11:117842497-117844120 (+)
AKR/J ENSMUSG00220044998
 protein coding gene Chr17:23299723-23306942 (+)
BALB/cJ ENSMUSG00180048848
 protein coding gene Chr17:23734168-23741371 (+)
C3H/HeJ ENSMUSG00175052198
 protein coding gene Chr17:23288229-23295445 (+)
C3H/HeJ ENSMUSG00175039298
 protein coding gene Chr11:117942571-117944195 (+)
C57BL/6NJ ENSMUSG00215052207
 protein coding gene Chr17:23286059-23293243 (+)
C57BL/6NJ ENSMUSG00215045155
 protein coding gene Chr11:117512621-117514246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021300
 protein coding gene Chr17:23403013-23410089 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210050004
 protein coding gene Chr11:117656608-117658232 (+)
CBA/J ENSMUSG00210046378
 protein coding gene Chr17:23126673-23133892 (+)
DBA/2J ENSMUSG00185022527
 protein coding gene Chr11:117969760-117971384 (+)
DBA/2J ENSMUSG00185050513
 protein coding gene Chr17:25340289-25347506 (+)
FVB/NJ ENSMUSG00205037784
 protein coding gene Chr11:117817483-117819109 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230044541
 protein coding gene Chr11:119036279-119037903 (+)
LP/J ENSMUSG00230054887
 protein coding gene Chr17:26863188-26870388 (+)
NOD/ShiLtJ ENSMUSG00190040951
 protein coding gene Chr11:118040986-118042610 (+)
NOD/ShiLtJ ENSMUSG00190049030
 protein coding gene Chr17:23233553-23240732 (+)
NZO/HlLtJ ENSMUSG00225050601
 protein coding gene Chr11:121184634-121186260 (+)
NZO/HlLtJ ENSMUSG00225050847
 protein coding gene Chr17:28827476-28834652 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGA1, high mobility group AT-hook 1
  • Synonyms
    HMGA1A, HMGIY, HMG-R
  • Links
    NCBI Gene ID: 3159
    UniProt: P17096

  • Chr Location
    6p21.31; chr6:34235618-34246236 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Hmga1 mouse models; 1 with human HMGA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1321
  • Tissues
    267
  • cDNA Data
    22
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046711 Ensembl Gene Model | MGI Sequence Detail 7178 C57BL/6J ±  kb
    transcript ENSMUST00000231866 Ensembl | MGI Sequence Detail 584 Not Applicable  
    polypeptide ENSMUSP00000155966 Ensembl | MGI Sequence Detail 118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 25
      Primer pair 5
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10796, MGI:2144347
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 27
      Diseases 3
      Gene Ontology 22
      Phenotypes 44
    • Earliest
      J:9471 Johnson KR, et al., Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem. 1988 Dec 5;263(34):18338-42
    • Latest
      J:379711 Ren W, et al., A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model. Adv Sci (Weinh). 2026 Jan 28;:e22890
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory