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H2-M2 Gene Detail
Summary
  • Symbol
    H2-M2
  • Name
    histocompatibility 2, M region locus 2
  • Synonyms
    H-2M2, Thy19.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95914
    NCBI Gene: 14990
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37791742-37794443 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95914
 protein coding gene Chr17:37791742-37794445 (-)
129S1/SvImJ ENSMUSG00200045784
 protein coding gene Chr17:33278884-33281580 (-)
A/J ENSMUSG00195035237
 protein coding gene Chr17:34456267-34458968 (-)
AKR/J ENSMUSG00220039633
 protein coding gene Chr17:33212940-33215652 (-)
BALB/cJ ENSMUSG00180034293
 protein coding gene Chr17:33961863-33964573 (-)
C3H/HeJ ENSMUSG00175039805
 protein coding gene Chr17:33153412-33156124 (-)
C57BL/6NJ ENSMUSG00215050317
 protein coding gene Chr17:33090124-33092825 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005049817
 protein coding gene Chr17:34320873-34323601 (-)
CBA/J ENSMUSG00210048855
 protein coding gene Chr17:32889639-32892349 (-)
DBA/2J ENSMUSG00185050956
 protein coding gene Chr17:35942768-35945472 (-)
FVB/NJ ENSMUSG00205026507
 protein coding gene Chr17:33454183-33456911 (-)
JF1/MsJ ENSUMUG00000028861
 protein coding gene Chr17:34886402-34889075 (-)
LP/J ENSMUSG00230054127
 protein coding gene Chr17:37073619-37076315 (-)
NOD/ShiLtJ ENSMUSG00190027780
 protein coding gene Chr17:33131455-33134156 (-)
NZO/HlLtJ ENSMUSG00225051298
 protein coding gene Chr17:39024731-39027435 (-)
PWK/PhJ ENSLUMG00010036594
 protein coding gene Chr17:32777377-32780113 (-)
SPRET/EiJ ENSMSPG00010049828
 protein coding gene Chr17:34033255-34035921 (-)
WSB/EiJ ENSIUOG00005047528
 protein coding gene Chr17:33982529-33985283 (-)



Homology
more
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353867-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722738-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-H, major histocompatibility complex, class I, H (pseudogene)
  • Synonyms
    HLAHP
  • Links
    NCBI Gene ID: 3136
    UniProt: P01893

  • Chr Location
    6p22.1; chr6:29887565-29924658 (+)  GRCh38
Human Diseases
more
  • Diseases
    46 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    48
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    24
  • cDNA Data
    6
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016283 Ensembl Gene Model | MGI Sequence Detail 2702 C57BL/6J ±  kb
transcript ENSMUST00000171139 Ensembl | MGI Sequence Detail 1298 Not Applicable  
polypeptide ENSMUSP00000131297 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    Q6W9L1 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 23
    Genomic 9
    cDNA 6
    Primer pair 1
    Other 7
    Antibodies 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10399, MGD-MRK-10510, MGD-MRK-15103
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:10054 Brorson KA, et al., Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics. 1989;30(4):273-83
  • Latest
    J:327971 Frederico B, et al., DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential. Dev Cell. 2022 Aug 22;57(16):1957-1975.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory