Slc39a7 MGI Mouse Gene Detail - MGI:95909 - solute carrier family 39 (zinc transporter), member 7

Symbol

Slc39a7
Name

solute carrier family 39 (zinc transporter), member 7
Synonyms

H2-Ke4, H-2Ke4, Ke-4, KE4, Ring5, Zip7

Feature Type

protein coding gene
IDs

MGI:95909
NCBI Gene: 14977
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:34247243-34250656 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

5 experiments

Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95909	protein coding gene	Chr17:34247240-34250664 (-)
129S1/SvImJ	ENSMUSG00200052554	protein coding gene	Chr17:29950549-29953731 (-)
A/J	ENSMUSG00195040374	protein coding gene	Chr17:30814546-30817728 (-)
AKR/J	ENSMUSG00220050407	protein coding gene	Chr17:29842186-29845368 (-)
BALB/cJ	ENSMUSG00180027906	protein coding gene	Chr17:30203486-30206669 (-)
C3H/HeJ	ENSMUSG00175052984	protein coding gene	Chr17:29728378-29731560 (-)
C57BL/6NJ	ENSMUSG00215053643	protein coding gene	Chr17:29790715-29793897 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021438	protein coding gene	Chr17:30357858-30361228 (-)
CAST/EiJ	ENSTCUG00005049693	protein coding gene	Chr17:30773960-30777146 (-)
CBA/J	ENSMUSG00210048463	protein coding gene	Chr17:29550480-29553662 (-)
DBA/2J	ENSMUSG00185052288	protein coding gene	Chr17:32222793-32225976 (-)
FVB/NJ	ENSMUSG00205050138	protein coding gene	Chr17:30079225-30082407 (-)
JF1/MsJ	ENSUMUG00000019143	protein coding gene	Chr17:31484045-31487229 (-)
LP/J	ENSMUSG00230053527	protein coding gene	Chr17:33348902-33352084 (-)
NOD/ShiLtJ	ENSMUSG00190053158	protein coding gene	Chr17:29702382-29705565 (-)
NZO/HlLtJ	ENSMUSG00225052022	protein coding gene	Chr17:35390900-35395775 (-)
PWK/PhJ	ENSLUMG00010040731	protein coding gene	Chr17:29329002-29332184 (-)
SPRET/EiJ	ENSMSPG00010035952	protein coding gene	Chr17:30472073-30475436 (-)
WSB/EiJ	ENSIUOG00005049492	protein coding gene	Chr17:30402762-30405945 (-)

Human Ortholog

SLC39A7, solute carrier family 39 member 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC39A7, solute carrier family 39 member 7
Synonyms

AGM9, D6S115E, D6S2244E, H2-KE4, HKE4, KE4, RING5, ZIP7
Links

HGNC:4927

NCBI Gene ID: 7922

UniProt: Q92504
Chr Location

6p21.32; chr6:33200305-33204439 (+) GRCh38

MGI Vertebrate Homology

Slc39a7 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SLC39A7
Gene Tree

Slc39a7

Diseases

1 with human SLC39A7 associations

				Human Disease	Mouse Models
				agammaglobulinemia 9 IDs agammaglobulinemia 9 DOID:0081141 OMIM:619693

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 4 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Slc39a7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in intestinal epithelial cells exhibit premature death, loss of epithelial integrity, reduced enterocyte proliferation and increased enterocyte apoptosis.

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All GO Annotations

34
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

57
cDNA Data

184
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a7

ZFIN slc39a7

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All Sequences

61
RefSeq

4
UniProt

4
CCDS

CCDS37576.1

Ensembl

ENSMUSG00000024327 (Evidence)
NCBI Gene

14977

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024327	Ensembl Gene Model \| MGI Sequence Detail	3414	C57BL/6J	± kb
transcript	ENSMUST00000169397	Ensembl \| MGI Sequence Detail	1550	Not Applicable
polypeptide	ENSMUSP00000130102	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015134 zinc transporter SLC39A7

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 199

Genomic 10

cDNA 187

Primer pair 2

Microarray probesets 2

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MGD-MRK-10394, MGD-MRK-10505, MGI:2146748, MGI:2146797, MGI:2146956

Summaries

All 66

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 13
Earliest

J:9525 Abe K, et al., Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. EMBO J. 1988 Nov;7(11):3441-9
Latest

J:366840 Brito S, et al., Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control. Dev Cell. 2025 May 5;60(9):1304-1320.e7

TSS for Slc39a7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147515	Chr17:34251019-34251035 (-)	-371 bp
Tssr147514	Chr17:34250658-34250673 (-)	-10 bp
Tssr147513	Chr17:34250645-34250648 (-)	9 bp
Tssr147512	Chr17:34250618-34250641 (-)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24