Gpt Gene Detail

Summary

• Symbol
  Gpt
• Name
  glutamic pyruvic transaminase, soluble
• Synonyms
  1300007J06Rik, 2310022B03Rik, ALT, Gpt-1, Gpt1

• Feature Type
  protein coding gene
• IDs
  MGI:95802
  NCBI Gene: 76282
• Alliance
  genome feature page
• Transcription Start Sites
  4 TSS
• Candidate for QTL
  4 QTL

Location &
Maps

• Sequence Map
  Chr15:76580926-76583875 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 36.28 cM, cytoband D3
• Mapping Data
  30 experiments

Strain
Comparison

• SNPs within 2kb
  119 from dbSNP Build 142
• Strain Annotations
  25

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95802	protein coding gene	Chr15:76579916-76583886 (+)
129S1/SvImJ	ENSMUSGG00200054961	protein coding gene	Chr15:73695252-73696440 (+)
129S1/SvImJ	ENSMUSG00200051244	protein coding gene	Chr15:73696608-73698045 (+)
A/J	ENSMUSG00195050769	protein coding gene	Chr15:73663887-73665330 (+)
A/J	ENSMUSGG00195055522	protein coding gene	Chr15:73662530-73663718 (+)
AKR/J	ENSMUSGG00220054305	protein coding gene	Chr15:73680760-73681948 (+)
AKR/J	ENSMUSG00220048684	protein coding gene	Chr15:73682116-73683553 (+)
BALB/cJ	ENSMUSG00180050304	protein coding gene	Chr15:73489023-73490466 (+)
BALB/cJ	ENSMUSGG00180054981	protein coding gene	Chr15:73487666-73488854 (+)
C3H/HeJ	ENSMUSG00175051430	protein coding gene	Chr15:73852446-73853889 (+)
C3H/HeJ	ENSMUSGG00175055157	protein coding gene	Chr15:73851090-73852278 (+)
C57BL/6NJ	ENSMUSGG00215055808	protein coding gene	Chr15:73587123-73588311 (+)
C57BL/6NJ	ENSMUSG00215049433	protein coding gene	Chr15:73588480-73589917 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019943	protein coding gene	Chr15:70642739-70645625 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210048421	protein coding gene	Chr15:73627650-73629093 (+)
CBA/J	ENSMUSGG00210055093	protein coding gene	Chr15:73626293-73627481 (+)
DBA/2J	ENSMUSGG00185057948	protein coding gene	Chr15:73610700-73611888 (+)
DBA/2J	ENSMUSG00185041700	protein coding gene	Chr15:73612056-73613493 (+)
FVB/NJ	ENSMUSG00205036898	protein coding gene	Chr15:73357147-73358590 (+)
FVB/NJ	ENSMUSGG00205054647	protein coding gene	Chr15:73355790-73356978 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055879	protein coding gene	Chr15:76969012-76970200 (+)
LP/J	ENSMUSG00230050381	protein coding gene	Chr15:76970369-76971812 (+)
NOD/ShiLtJ	ENSMUSGG00190055118	protein coding gene	Chr15:73609869-73611057 (+)
NZO/HlLtJ	ENSMUSGG00225055583	protein coding gene	Chr15:77283968-77285156 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010040023	protein coding gene	Chr15:75158620-75162529 (+)
WSB/EiJ	no annotation

Homology

• Human Ortholog
  GPT, glutamic--pyruvic transaminase

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GPT, glutamic--pyruvic transaminase
  
• Synonyms
  AAT1, ALT, ALT1, GPT1, SGPT
• Links
  HGNC:4552

  NCBI Gene ID: 2875

  UniProt: P24298

  
  
• Chr Location
  8q24.3; chr8:144502608-144507494 (+)  GRCh38

---

• MGI Vertebrate Homology
  Gpt stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: GPT
• Gene Tree
  Gpt
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  32 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (other)
  3
• Endonuclease-mediated
  3
• Radiation induced
  2
• Targeted
  4
• Genomic Mutations
  5 involving Gpt
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  25 strains or lines available

Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  15
• GO References
  13

Expression

• Assay Results
  738
• Tissues
  112
• cDNA Data
  12
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gpt
  ZFIN gpt

Sequences &
Gene Models

• All Sequences
  61
• RefSeq
  2
• UniProt
  5
• CCDS
  CCDS27586.1

• Ensembl
  ENSMUSG00000022546 (Evidence)
• NCBI Gene
  76282

Representative Sequences			Length	Strain/Species
genomic	76282	NCBI Gene Model | MGI Sequence Detail	2950	C57BL/6J
transcript	NM_182805	RefSeq | MGI Sequence Detail	1809	ZRU/MplStud
polypeptide	Q8QZR5	UniProt | EBI | MGI Sequence Detail	496	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000008208 alanine aminotransferase 1
  (term hierarchy)
• EC
  2.6.1.2
• InterPro Domains
  IPR045088 Aminotransferase ALAT1/2-like
  IPR004839 Aminotransferase, class I/classII, large domain
  IPR015424 Pyridoxal phosphate-dependent transferase
  IPR015421 Pyridoxal phosphate-dependent transferase, major domain
  IPR015422 Pyridoxal phosphate-dependent transferase, small domain
• GlyGen
  Q8QZR5 2 sites, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-10236, MGD-MRK-10237, MGI:1915263, MGI:1923532

References

• Summaries
  All 86

  Developmental Gene Expression 2

  Diseases 1

  Gene Ontology 13

  Phenotypes 32
• Earliest
  J:5384 Chen SH, et al., The genetics of glutamic-pyruvic transaminase in mice: inheritance, electrophoretic phenotypes, and postnatal changes. Biochem Genet. 1973 Sep;10(1):23-8
• Latest
  J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Gpt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131817	Chr15:76579885-76579902 (+)	-1,032 bp
Tssr131818	Chr15:76579965-76579987 (+)	-950 bp
Tssr131819	Chr15:76580925-76580947 (+)	10 bp
Tssr131820	Chr15:76582372-76582421 (+)	1,471 bp

Gpt is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw11	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Bwtq6	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Dbsty4	Chr15, 41.96 cM	Chr15:87349271-87349416	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Mobq4	Chr15, 1.84 cM	Chr15:3489694-3489829	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.

*cM position of peak correlated region/marker