Grk4 MGI Mouse Gene Detail - MGI:95801 - G protein-coupled receptor kinase 4

Symbol

Grk4
Name

G protein-coupled receptor kinase 4
Synonyms

A830025H08Rik, Gprk2l

Feature Type

protein coding gene
IDs

MGI:95801
NCBI Gene: 14772
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:34817723-34912649 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.91 cM
Mapping Data

4 experiments

SNPs within 2kb

231 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95801	protein coding gene	Chr5:34817641-34912649 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029470	protein coding gene	Chr5:32909507-33006371 (+)
A/J	MGP_AJ_G0029437	protein coding gene	Chr5:31822556-31918265 (+)
AKR/J	MGP_AKRJ_G0029386	protein coding gene	Chr5:33047444-33149520 (+)
BALB/cJ	MGP_BALBcJ_G0029447	protein coding gene	Chr5:32354944-32451071 (+)
C3H/HeJ	MGP_C3HHeJ_G0029169	protein coding gene	Chr5:33082643-33180634 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029901	protein coding gene	Chr5:34796753-34892255 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027138	protein coding gene	Chr5:29601165-29699733 (+)
CAST/EiJ	MGP_CASTEiJ_G0028578	protein coding gene	Chr5:32150769-32254084 (+)
CBA/J	MGP_CBAJ_G0029137	protein coding gene	Chr5:35588162-35694862 (+)
DBA/2J	MGP_DBA2J_G0029285	protein coding gene	Chr5:31991215-32084603 (+)
FVB/NJ	MGP_FVBNJ_G0029244	protein coding gene	Chr5:31431168-31525704 (+)
LP/J	MGP_LPJ_G0029370	protein coding gene	Chr5:33326805-33423968 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029274	protein coding gene	Chr5:36434372-36533223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029934	protein coding gene	Chr5:32554198-32663853 (+)
PWK/PhJ	MGP_PWKPhJ_G0028303	protein coding gene	Chr5:31138118-31233758 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028134	protein coding gene	Chr5:31986013-32093763 (+)
WSB/EiJ	MGP_WSBEiJ_G0028659	protein coding gene	Chr5:32633017-32727318 (+)

Human Ortholog

GRK4, G protein-coupled receptor kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRK4, G protein-coupled receptor kinase 4
Synonyms

GPRK2L, GPRK4, GRK4a, IT11
Links

HGNC:4543

NCBI Gene ID: 2868

neXtProt AC: NX_P32298

UniProt: P32298
Chr Location

4p16.3; chr4:2963571-3040760 (+) GRCh38

MGI Vertebrate Homology

Grk4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRK4
Gene Tree

Grk4

Diseases

1 with human GRK4 associations

				Human Disease	Mouse Models
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotype references

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

5
Spontaneous

1
Targeted

2
Genomic Mutations

9 involving Grk4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

40
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grk4

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All Sequences

71
RefSeq

32
UniProt

4
CCDS

CCDS19219.1, CCDS39070.1

Ensembl

ENSMUSG00000052783 (Evidence)
NCBI Gene

14772

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052783	Ensembl Gene Model \| MGI Sequence Detail	94927	C57BL/6J	± kb
transcript	ENSMUST00000001112	Ensembl \| MGI Sequence Detail	2408	Not Applicable
polypeptide	ENSMUSP00000001112	Ensembl \| MGI Sequence Detail	574	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008258 G protein-coupled receptor kinase 4

(term hierarchy)
EC

2.7.11.16
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000239 GPCR kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-10235, MGI:1924341

Summaries

All 60

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 29
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:326977 Banna FKE, et al., Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Sci Rep. 2022 Jun 4;12(1):9336

TSS for Grk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45897	Chr5:34817638-34817646 (+)	-81 bp
Tssr45898	Chr5:34817653-34817667 (+)	-63 bp
Tssr45899	Chr5:34817705-34817755 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23