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Gna13 Gene Detail
Summary
  • Symbol
    Gna13
  • Name
    guanine nucleotide binding protein, alpha 13
  • Synonyms
    Galpha13
  • Feature Type
    protein coding gene
  • IDs
    MGI:95768
    NCBI Gene: 14674
  • Alliance
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109253657-109292195 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.88 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95768
protein coding gene Chr11:109253620-109292195 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019331
protein coding gene Chr11:112916241-112955725 (+)
A/J MGP_AJ_G0019299
protein coding gene Chr11:108032510-108070737 (+)
AKR/J MGP_AKRJ_G0019268
protein coding gene Chr11:111264405-111307300 (+)
BALB/cJ MGP_BALBcJ_G0019273
protein coding gene Chr11:108463074-108502546 (+)
C3H/HeJ MGP_C3HHeJ_G0019082
protein coding gene Chr11:111573523-111617188 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019723
protein coding gene Chr11:116338124-116378158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017347
protein coding gene Chr11:105262257-105301147 (+)
CAST/EiJ MGP_CASTEiJ_G0018636
protein coding gene Chr11:112695998-112734278 (+)
CBA/J MGP_CBAJ_G0019051
protein coding gene Chr11:121146871-121185191 (+)
DBA/2J MGP_DBA2J_G0019163
protein coding gene Chr11:107509860-107548327 (+)
FVB/NJ MGP_FVBNJ_G0019154
protein coding gene Chr11:106997523-107036109 (+)
LP/J MGP_LPJ_G0019233
protein coding gene Chr11:113328179-113367387 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019185
protein coding gene Chr11:120295472-120335729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019760
protein coding gene Chr11:111833281-111874602 (+)
PWK/PhJ MGP_PWKPhJ_G0018401
protein coding gene Chr11:108670650-108709200 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018191
protein coding gene Chr11:111610223-111650579 (+)
WSB/EiJ MGP_WSBEiJ_G0018687
protein coding gene Chr11:111755841-111796938 (+)



Homology
more
  • Human Ortholog
    GNA13, G protein subunit alpha 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA13, G protein subunit alpha 13
  • Synonyms
    G13, HG1N
  • Links
    NCBI Gene ID: 10672
    neXtProt AC: NX_Q14344
    UniProt: Q14344

  • Chr Location
    17q24.1; chr17:65009289-65056740 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 6 alleles in 7 genetic backgrounds
    27 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null or with an endothelial specific conditional mutation fail to develop an organized vascular system in the yolk sac, show impaired vascular development in some vascular beds in the embryo proper, and die during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020611 Ensembl Gene Model | MGI Sequence Detail 38539 C57BL/6J ±  kb
    transcript ENSMUST00000020930 Ensembl | MGI Sequence Detail 6160 Not Applicable  
    polypeptide ENSMUSP00000020930 Ensembl | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 229
      cDNA 224
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10177, MGI:2144419, MGI:2144437
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 15
      Gene Ontology 20
      Phenotypes 57
    • Earliest
      J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
    • Latest
      J:346729 Liu D, et al., Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function. Nat Immunol. 2024 Jan;25(1):142-154

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    05/14/2024
    MGI 6.23
    The Jackson Laboratory