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Glra2 Gene Detail
Summary
  • Symbol
    Glra2
  • Name
    glycine receptor, alpha 2 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95748
    NCBI Gene: 237213
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:163912013-164110389 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4130 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95748
 protein coding gene ChrX:163912013-164110863 (-)
129S1/SvImJ ENSMUSG00200025196
 protein coding gene ChrX:140648817-140846920 (-)
A/J ENSMUSG00195015127
 protein coding gene ChrX:145772577-145970701 (-)
AKR/J ENSMUSG00220027494
 protein coding gene ChrX:137653493-137851617 (-)
BALB/cJ ENSMUSG00180036961
 protein coding gene ChrX:141159186-141357298 (-)
C3H/HeJ ENSMUSG00175010078
 protein coding gene ChrX:145706558-145904662 (-)
C57BL/6NJ ENSMUSG00215020348
 protein coding gene ChrX:141530419-141728805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033568
 protein coding gene ChrX:153395888-153598243 (-)
CAST/EiJ ENSTCUG00005023433
 protein coding gene ChrX:143229594-143426288 (-)
CBA/J ENSMUSG00210029051
 protein coding gene ChrX:143119649-143317756 (-)
DBA/2J ENSMUSG00185029541
 protein coding gene ChrX:157975816-158173930 (-)
FVB/NJ ENSMUSG00205030490
 protein coding gene ChrX:141630343-141828457 (-)
JF1/MsJ ENSUMUG00000033806
 protein coding gene ChrX:178358581-178562559 (-)
LP/J ENSMUSG00230024836
 protein coding gene ChrX:164765695-164963796 (-)
NOD/ShiLtJ ENSMUSG00190031273
 protein coding gene ChrX:142153954-142352042 (-)
NZO/HlLtJ ENSMUSG00225037810
 protein coding gene ChrX:168154064-168352200 (-)
PWK/PhJ ENSLUMG00010042134
 protein coding gene ChrX:139423533-139644450 (-)
SPRET/EiJ ENSMSPG00010024971
 protein coding gene ChrX:144728460-144954891 (-)
WSB/EiJ ENSIUOG00005010862
 protein coding gene ChrX:142576575-142774992 (-)



Homology
more
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
  • Synonyms
    GLR, MRXSP
  • Links
    NCBI Gene ID: 2742
    UniProt: P23416

  • Chr Location
    Xp22.2; chrX:14448779-14731812 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GLRA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack cortical neuron responses to glycine and taurine but are otherwise normal. Mice homozygous for another targeted allele exhibit impaired interneuron migration into the cortical wall.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    668
  • Tissues
    21
  • cDNA Data
    10
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018589 Ensembl Gene Model | MGI Sequence Detail 198377 C57BL/6J ±  kb
    transcript ENSMUST00000058787 Ensembl | MGI Sequence Detail 3150 Not Applicable  
    polypeptide ENSMUSP00000060827 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008043 glycine receptor subunit alpha-2
      (term hierarchy)
    • InterPro Domains
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR008127 Glycine receptor alpha
      IPR008129 Glycine receptor alpha2
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      Q7TNC8 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 9
      cDNA 13
      Primer pair 1
      Other 3
      Antibodies 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10131
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
    • Latest
      J:385984 San Martin LS, et al., Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits. Life Sci. 2024 Jul 1;348:122673
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory