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B4galt1 Gene Detail
Summary
  • Symbol
    B4galt1
  • Name
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
  • Synonyms
    b1,4-Galactosyltransferase I, B-1,4-GalT1, beta 1,4-Galactosyltransferase I, beta-1,4-GalT1, GalT, Ggtb, Ggtb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95705
    NCBI Gene: 14595
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40804602-40854005 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.46 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95705
 protein coding gene Chr4:40804602-40855711 (-)
129S1/SvImJ ENSMUSG00200004848
 protein coding gene Chr4:37646433-37695840 (-)
A/J ENSMUSG00195003004
 protein coding gene Chr4:38022241-38071714 (-)
AKR/J ENSMUSG00220030377
 protein coding gene Chr4:37850304-37899779 (-)
BALB/cJ ENSMUSG00180025498
 protein coding gene Chr4:37609075-37658478 (-)
C3H/HeJ ENSMUSG00175022131
 protein coding gene Chr4:37987713-38037181 (-)
C57BL/6NJ ENSMUSG00215022571
 protein coding gene Chr4:37625339-37674751 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025900
 protein coding gene Chr4:34901447-34948670 (-)
CAST/EiJ ENSTCUG00005004053
 protein coding gene Chr4:37471124-37521444 (-)
CBA/J ENSMUSG00210007436
 protein coding gene Chr4:37688680-37738088 (-)
DBA/2J ENSMUSG00185005820
 protein coding gene Chr4:37762415-37811824 (-)
FVB/NJ ENSMUSG00205025690
 protein coding gene Chr4:37313154-37362572 (-)
JF1/MsJ ENSUMUG00000009369
 protein coding gene Chr4:37694706-37744837 (-)
LP/J ENSMUSG00230041494
 protein coding gene Chr4:41140048-41189451 (-)
NOD/ShiLtJ ENSMUSG00190005616
 protein coding gene Chr4:37711631-37761103 (-)
NZO/HlLtJ ENSMUSG00225006495
 protein coding gene Chr4:45020649-45070056 (-)
PWK/PhJ ENSLUMG00010005689
 protein coding gene Chr4:37215546-37265426 (-)
SPRET/EiJ ENSMSPG00010022640
 protein coding gene Chr4:38199164-38246091 (-)
WSB/EiJ ENSIUOG00005046356
 protein coding gene Chr4:37559273-37608747 (-)



Homology
more
  • Human Ortholog
    B4GALT1, beta-1,4-galactosyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B4GALT1, beta-1,4-galactosyltransferase 1
  • Synonyms
    B4GAL-T1, beta4Gal-T1, CDG2D, CLDLFIB, GGTB2, GT1, GTB
  • Links
    NCBI Gene ID: 2683
    UniProt: P15291

  • Chr Location
    9p21.1; chr9:33100493-33185089 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with B4galt1 mouse models; 2 with human B4GALT1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 4 alleles in 4 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit growth retardation, low viability, excessive epithelial cell proliferation of skin and small intestine, sperm with reduced fertilizing capacity, birthing difficulty, and mammary gland defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    110
  • cDNA Data
    173
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028413 Ensembl Gene Model | MGI Sequence Detail 49404 C57BL/6J ±  kb
    transcript ENSMUST00000030121 Ensembl | MGI Sequence Detail 3983 Not Applicable  
    polypeptide ENSMUSP00000030121 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 1
      cDNA 178
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10067, MGI:2140118, MGI:891991
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 28
      Phenotypes 38
    • Earliest
      J:8592 Shaper NL, et al., The gene for galactosyltransferase maps to mouse chromosome 4. Cytogenet Cell Genet. 1987;44(1):18-21
    • Latest
      J:343168 Wei H, et al., Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice. Front Immunol. 2023;14:1272537
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory