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Gbp2b Gene Detail
Summary
  • Symbol
    Gbp2b
  • Name
    guanylate binding protein 2b
  • Synonyms
    Gbp-1, Gbp1, LIMIT, Mag-1, Mpa-1, Mpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95666
    NCBI Gene: 14468
  • Alliance
    genome feature page
  • Transcription Start Sites
    36 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:142300608-142324940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1139 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95666
 protein coding gene Chr3:142300577-142324940 (+)
129S1/SvImJ ENSMUSG00200002368
 protein coding gene Chr3:139083375-139139194 (+)
A/J ENSMUSG00195003962
 protein coding gene Chr3:139216194-139315614 (+)
AKR/J ENSMUSG00220003163
 protein coding gene Chr3:137637093-137709441 (+)
BALB/cJ ENSMUSG00180011404
 protein coding gene Chr3:139105243-139186248 (+)
C3H/HeJ ENSMUSG00175019062
 protein coding gene Chr3:138713913-138769730 (+)
C57BL/6NJ ENSMUSG00215022728
 protein coding gene Chr3:139483484-139507818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025695
 protein coding gene Chr3:135859367-135888012 (+)
CAST/EiJ ENSTCUG00005027824
 protein coding gene Chr3:139841524-139925050 (+)
CBA/J ENSMUSG00210029403
 protein coding gene Chr3:139370423-139454760 (+)
DBA/2J ENSMUSG00185003236
 protein coding gene Chr3:139963726-140036010 (+)
FVB/NJ ENSMUSG00205022756
 protein coding gene Chr3:138257600-138331375 (+)
JF1/MsJ ENSUMUG00000002732
 protein coding gene Chr3:138767503-138855141 (+)
LP/J ENSMUSG00230003042
 protein coding gene Chr3:141896132-141951944 (+)
NOD/ShiLtJ ENSMUSG00190004420
 protein coding gene Chr3:140330898-140403247 (+)
NZO/HlLtJ ENSMUSG00225002201
 protein coding gene Chr3:144380901-144453240 (+)
PWK/PhJ ENSLUMG00010020542
 protein coding gene Chr3:138667329-138755392 (+)
SPRET/EiJ ENSMSPG00010013287
 protein coding gene Chr3:139930051-139996040 (+)
WSB/EiJ ENSIUOG00005018259
 protein coding gene Chr3:139481640-139561080 (+)



Homology
more
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Synonyms
    hGBP1
  • Links
    NCBI Gene ID: 2633
    UniProt: P32455

  • Chr Location
    1p22.2; chr1:89051505-89072769 (-)  GRCh38
  • Human Ortholog
    GBP2, guanylate binding protein 2
  • Links
    NCBI Gene ID: 2634
    UniProt: P32456

  • Chr Location
    1p22.2; chr1:89106132-89150456 (-)  GRCh38
  • Human Ortholog
    GBP3, guanylate binding protein 3
  • Links
    NCBI Gene ID: 2635
    UniProt: Q9H0R5

  • Chr Location
    1p22.2; chr1:89006666-89022894 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040264 Ensembl Gene Model | MGI Sequence Detail 24333 C57BL/6J ±  kb
    transcript ENSMUST00000029936 Ensembl | MGI Sequence Detail 2823 Not Applicable  
    polypeptide ENSMUSP00000029936 Ensembl | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      3.6.1.-, 3.6.5.-
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR037684 Guanylate-binding protein, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10008, MGD-MRK-10009, MGD-MRK-12400, MGD-MRK-12402, MGI:97071
    References
    more
    • Summaries
      All 93
      Diseases 1
      Gene Ontology 13
      Phenotypes 38
    • Earliest
      J:7579 Staeheli P, et al., Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property. Virology. 1984 Aug;137(1):135-42
    • Latest
      J:382922 Pizzuto M, et al., Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. EMBO J. 2025 Aug;44(16):4419-4442
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory