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Galt Gene Detail
Summary
  • Symbol
    Galt
  • Name
    galactose-1-phosphate uridyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:95638
    NCBI Gene: 14430
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41755228-41758695 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.07 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    23
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95638
 protein coding gene Chr4:41755228-41759243 (+)
129S1/SvImJ ENSMUSG00200003987
 protein coding gene Chr4:38603177-38604346 (+)
129S1/SvImJ ENSMUSGG00200054416
 protein coding gene Chr4:38604437-38606619 (+)
A/J ENSMUSGG00195055140
 protein coding gene Chr4:38975115-38977297 (+)
A/J ENSMUSG00195003098
 protein coding gene Chr4:38973855-38975024 (+)
AKR/J ENSMUSGG00220054884
 protein coding gene Chr4:38804461-38806508 (+)
AKR/J ENSMUSG00220031332
 protein coding gene Chr4:38803053-38804229 (+)
BALB/cJ ENSMUSG00180024152
 protein coding gene Chr4:38560675-38561844 (+)
BALB/cJ ENSMUSGG00180055256
 protein coding gene Chr4:38561935-38564117 (+)
C3H/HeJ ENSMUSGG00175054930
 protein coding gene Chr4:38940533-38942715 (+)
C3H/HeJ ENSMUSG00175022473
 protein coding gene Chr4:38939273-38940442 (+)
C57BL/6NJ ENSMUSGG00215055465
 protein coding gene Chr4:38578153-38580335 (+)
C57BL/6NJ ENSMUSG00215014676
 protein coding gene Chr4:38576893-38578062 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210007079
 protein coding gene Chr4:38640168-38641337 (+)
CBA/J ENSMUSGG00210054990
 protein coding gene Chr4:38641428-38643610 (+)
DBA/2J ENSMUSG00185006187
 protein coding gene Chr4:38713964-38715133 (+)
DBA/2J ENSMUSGG00185057593
 protein coding gene Chr4:38715224-38717406 (+)
FVB/NJ ENSMUSGG00205054257
 protein coding gene Chr4:38266093-38268275 (+)
FVB/NJ ENSMUSG00205017751
 protein coding gene Chr4:38264833-38266002 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055424
 protein coding gene Chr4:42097968-42100150 (+)
LP/J ENSMUSG00230039693
 protein coding gene Chr4:42096708-42097877 (+)
NOD/ShiLtJ ENSMUSG00190005106
 protein coding gene Chr4:38663550-38669106 (+)
NZO/HlLtJ ENSMUSG00225006719
 protein coding gene Chr4:45971939-45978039 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GALT, galactose-1-phosphate uridylyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALT, galactose-1-phosphate uridylyltransferase
  • Links
    NCBI Gene ID: 2592
    UniProt: P07902

  • Chr Location
    9p13.3; chr9:34637367-34651754 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Galt mouse models; 1 with human GALT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit abnormal galactose metabolism, but lack symptoms of acute toxicity seen in humans with galactosemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    112
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036073 Ensembl Gene Model | MGI Sequence Detail 3468 C57BL/6J ±  kb
    transcript ENSMUST00000084695 Ensembl | MGI Sequence Detail 1595 Not Applicable  
    polypeptide ENSMUSP00000081745 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000007834 galactose-1-phosphate uridylyltransferase
      (term hierarchy)
    • EC
      2.7.7.12
    • InterPro Domains
      IPR001937 Galactose-1-phosphate uridyl transferase, class I
      IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site
      IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal
      IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal
      IPR036265 HIT-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 10
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9964, MGI:2147374
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory