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Cidec Gene Detail
Summary
  • Symbol
    Cidec
  • Name
    cell death-inducing DFFA-like effector c
  • Synonyms
    CIDE-3, CIDE-3alpha, Fsp27
  • Feature Type
    protein coding gene
  • IDs
    MGI:95585
    NCBI Gene: 14311
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113401595-113412721 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.76 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95585
 protein coding gene Chr6:113401595-113412721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031123
 protein coding gene Chr6:115942628-115953575 (-)
A/J MGP_AJ_G0031092
 protein coding gene Chr6:111501805-111511892 (-)
AKR/J MGP_AKRJ_G0031023
 protein coding gene Chr6:114496675-114505896 (-)
BALB/cJ MGP_BALBcJ_G0031103
 protein coding gene Chr6:111448537-111457639 (-)
C3H/HeJ MGP_C3HHeJ_G0030605
 protein coding gene Chr6:69792509-69801639 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031562
 protein coding gene Chr6:118948066-118959075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028726
 protein coding gene Chr6:108505942-108539115 (-)
CAST/EiJ MGP_CASTEiJ_G0030210
 protein coding gene Chr6:114936859-114949015 (-)
CBA/J MGP_CBAJ_G0030789
 protein coding gene Chr6:123642668-123654790 (-)
DBA/2J MGP_DBA2J_G0030942
 protein coding gene Chr6:110582124-110591302 (-)
FVB/NJ MGP_FVBNJ_G0030896
 protein coding gene Chr6:109581422-109590694 (-)
LP/J MGP_LPJ_G0031022
 protein coding gene Chr6:115981313-115990468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030930
 protein coding gene Chr6:127908740-127918970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031589
 protein coding gene Chr6:114510104-114520189 (-)
PWK/PhJ MGP_PWKPhJ_G0029926
 protein coding gene Chr6:109536276-109546997 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029754
 protein coding gene Chr6:113325140-113337056 (-)
WSB/EiJ MGP_WSBEiJ_G0030294
 protein coding gene Chr6:114884010-114894588 (-)



Homology
more
  • Human Ortholog
    CIDEC, cell death inducing DFFA like effector c
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIDEC, cell death inducing DFFA like effector c
  • Synonyms
    CIDE3, CIDE-3, FPLD5, FSP27
  • Links
    NCBI Gene ID: 63924
    neXtProt AC: NX_Q96AQ7
    UniProt: Q96AQ7

  • Chr Location
    3p25.3; chr3:9866710-9880255 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CIDEC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit leaness, high energy expenditure, improved glucose tolerance, altered brown adipocytes, and multilocular fat droplets with enhanced mitochondrial activity and lipolysis in white adipocytes, and may show resistance to age related and diet-induced obesity and liver steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    47
  • cDNA Data
    50
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14311 NCBI Gene Model | MGI Sequence Detail 11127 C57BL/6J ±  kb
    transcript NM_001301295 RefSeq | MGI Sequence Detail 1720 C57BL/6  
    polypeptide P56198 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 50
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9879
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:154 Danesch U, et al., Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem. 1992 Apr 5;267(10):7185-93
    • Latest
      J:333997 Qian K, et al., CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 Jan;613(7942):160-168
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory