About   Help   FAQ
Foxs1 Gene Detail
Summary
  • Symbol
    Foxs1
  • Name
    forkhead box S1
  • Synonyms
    Fkh3, Fkhl18, FREAC10
  • Feature Type
    protein coding gene
  • IDs
    MGI:95546
    NCBI Gene: 14239
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152773818-152775128 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95546
 protein coding gene Chr2:152773818-152775128 (-)
129S1/SvImJ ENSMUSG00200027697
 protein coding gene Chr2:149690422-149691732 (-)
A/J ENSMUSG00195017664
 protein coding gene Chr2:149961624-149962933 (-)
AKR/J ENSMUSG00220041460
 protein coding gene Chr2:149282621-149283931 (-)
BALB/cJ ENSMUSG00180043582
 protein coding gene Chr2:149448622-149449932 (-)
C3H/HeJ ENSMUSG00175043360
 protein coding gene Chr2:150194829-150196139 (-)
C57BL/6NJ ENSMUSG00215021015
 protein coding gene Chr2:149617249-149618559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024476
 protein coding gene Chr2:144822464-144823773 (-)
CAST/EiJ ENSTCUG00005039389
 protein coding gene Chr2:148544248-148545558 (-)
CBA/J ENSMUSG00210039710
 protein coding gene Chr2:150131349-150132659 (-)
DBA/2J ENSMUSG00185043241
 protein coding gene Chr2:149781732-149783042 (-)
FVB/NJ ENSMUSG00205028065
 protein coding gene Chr2:148878547-148879857 (-)
JF1/MsJ ENSUMUG00000029873
 protein coding gene Chr2:149450300-149451609 (-)
LP/J ENSMUSG00230033883
 protein coding gene Chr2:151438838-151440148 (-)
NOD/ShiLtJ ENSMUSG00190033469
 protein coding gene Chr2:149549531-149550840 (-)
NZO/HlLtJ ENSMUSG00225003655
 protein coding gene Chr2:159469761-159471071 (-)
PWK/PhJ ENSLUMG00010042109
 protein coding gene Chr2:149418000-149419310 (-)
SPRET/EiJ ENSMSPG00010026005
 protein coding gene Chr2:152142408-152143718 (-)
WSB/EiJ ENSIUOG00005040596
 protein coding gene Chr2:149285537-149286847 (-)



Homology
more
  • Human Ortholog
    FOXS1, forkhead box S1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXS1, forkhead box S1
  • Synonyms
    FKHL18, FREAC-10, FREAC10
  • Links
    NCBI Gene ID: 2307
    UniProt: O43638

  • Chr Location
    20q11.21; chr20:31844303-31845604 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one reporter allele display enhanced rotarod performance and increased male resistance to diet-induced obesity. Homozygotes for another reporter allele show impaired testicular vasculature, including blood accumulation in fetal testis and marked apoptosis of periendothelial cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    74
  • cDNA Data
    21
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14239 NCBI Gene Model | MGI Sequence Detail 1311 C57BL/6J ±  kb
    transcript NM_010226 RefSeq | MGI Sequence Detail 1311 C57BL/6  
    polypeptide Q61574 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 22
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9815
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory