About   Help   FAQ
Fcgr1 Gene Detail
Summary
  • Symbol
    Fcgr1
  • Name
    Fc receptor, IgG, high affinity I
  • Synonyms
    CD64, FcgammaRI
  • Feature Type
    protein coding gene
  • IDs
    MGI:95498
    NCBI Gene: 14129
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96190225-96201285 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.72 cM
  • Mapping Data
    18 experiments
  • Sequence Tag
    D3Nds11
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95498
 protein coding gene Chr3:96190225-96201285 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027616
 protein coding gene Chr3:97093778-97103983 (-)
A/J MGP_AJ_G0027578
 protein coding gene Chr3:94046916-94086092 (-)
AKR/J MGP_AKRJ_G0027545
 protein coding gene Chr3:96253911-96297938 (-)
BALB/cJ MGP_BALBcJ_G0027588
 protein coding gene Chr3:93835229-93846011 (-)
C3H/HeJ MGP_C3HHeJ_G0027320
 protein coding gene Chr3:96535025-96545227 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028034
 protein coding gene Chr3:100653575-100664590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025376
 protein coding gene Chr3:90368921-90378992 (-)
CAST/EiJ MGP_CASTEiJ_G0026773
 protein coding gene Chr3:95851007-95880082 (-)
CBA/J MGP_CBAJ_G0027295
 protein coding gene Chr3:104339634-104349695 (-)
DBA/2J MGP_DBA2J_G0027438
 protein coding gene Chr3:93350377-93360498 (-)
FVB/NJ MGP_FVBNJ_G0027407
 protein coding gene Chr3:91408150-91451605 (-)
LP/J MGP_LPJ_G0027543
 protein coding gene Chr3:98420330-98482645 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027433
 protein coding gene Chr3:110429802-110443855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028088
 protein coding gene Chr3:95884266-95898932 (-)
PWK/PhJ MGP_PWKPhJ_G0026500
 protein coding gene Chr3:93247394-93287461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026322
 protein coding gene Chr3:94186956-94219153 (-)
WSB/EiJ MGP_WSBEiJ_G0026853
 protein coding gene Chr3:96277545-96364988 (-)



Homology
more
  • Human Ortholog
    FCGR1A, Fc gamma receptor Ia
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCGR1A, Fc gamma receptor Ia
  • Synonyms
    CD64, CD64A, FCG1, FcgammaRI, FCGR1, FCRI, IGFR1
  • Links
    NCBI Gene ID: 2209
    neXtProt AC: NX_P12314
    UniProt: P12314

  • Chr Location
    1q21.2; chr1:149782677-149792518 (+)  GRCh38.p7
  • Human Ortholog
    FCGR1BP, Fc gamma receptor Ib, pseudogene
  • Synonyms
    CD34, CD64b, FCG1, FcgammaRIa, FCGR1, FCGR1B, FcRI, IGFR1, IGFRB
  • Links
    NCBI Gene ID: 2210
    UniProt: Q92637

  • Chr Location
    1p11.2; chr1:121087345-121097161 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results immune response defects including a decreased inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14129 NCBI Gene Model | MGI Sequence Detail 11061 C57BL/6J ±  kb
    transcript NM_010186 RefSeq | MGI Sequence Detail 2589 C57BL/6  
    polypeptide P26151 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 4
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9732, MGI:2139673, MGI:2139933
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 100
    • Earliest
      J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
    • Latest
      J:330538 Sahin M, et al., Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors. Cell Rep. 2022 Feb 1;38(5):110303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Copyright, and Privacy Statement
    Send questions and comments to User Support.     		last database update
    01/24/2023
    MGI 6.22     		The Jackson Laboratory