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Fabp2 Gene Detail
Summary
  • Symbol
    Fabp2
  • Name
    fatty acid binding protein 2, intestinal
  • Synonyms
    Fabpi, Fabpi, I-FABP
  • Feature Type
    protein coding gene
  • IDs
    MGI:95478
    NCBI Gene: 14079
  • Alliance
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:122688721-122693155 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 53.74 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95478
protein coding gene Chr3:122688721-122693155 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027842
protein coding gene Chr3:125185655-125190087 (+)
A/J MGP_AJ_G0027801
protein coding gene Chr3:120996095-121000528 (+)
AKR/J MGP_AKRJ_G0027766
protein coding gene Chr3:124085966-124090400 (+)
BALB/cJ MGP_BALBcJ_G0027813
protein coding gene Chr3:120811482-120815915 (+)
C3H/HeJ MGP_C3HHeJ_G0027543
protein coding gene Chr3:124481434-124485867 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028258
protein coding gene Chr3:129727535-129731969 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025597
protein coding gene Chr3:116422196-116426622 (+)
CAST/EiJ MGP_CASTEiJ_G0026999
protein coding gene Chr3:123878426-123882861 (+)
CBA/J MGP_CBAJ_G0027518
protein coding gene Chr3:134109184-134113617 (+)
DBA/2J MGP_DBA2J_G0027659
protein coding gene Chr3:120123614-120128048 (+)
FVB/NJ MGP_FVBNJ_G0027627
protein coding gene Chr3:117739899-117744333 (+)
LP/J MGP_LPJ_G0027769
protein coding gene Chr3:126701744-126706176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027657
protein coding gene Chr3:141658066-141663048 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028314
protein coding gene Chr3:123644582-123649016 (+)
PWK/PhJ MGP_PWKPhJ_G0026725
protein coding gene Chr3:119850836-119855322 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026548
protein coding gene Chr3:121742691-121747105 (+)
WSB/EiJ MGP_WSBEiJ_G0027079
protein coding gene Chr3:124380371-124384804 (+)



Homology
more
  • Human Ortholog
    FABP2, fatty acid binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FABP2, fatty acid binding protein 2
  • Synonyms
    FABPI, I-FABP
  • Links
    NCBI Gene ID: 2169
    neXtProt AC: NX_P12104
    UniProt: P12104

  • Chr Location
    4q26; chr4:119317250-119322138 (-)  GRCh38

Human Diseases
more
  • Diseases
    5 with human FABP2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mutant mice exhibit increased body weight, hyperinsulinemia, increased leptin levels on a high fat diet and have elevated circulating levels of triglycerides. Female mutant mice exhibit a decreased body weight on a high fat diet compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14079 NCBI Gene Model | MGI Sequence Detail 4435 C57BL/6J ±  kb
    transcript NM_007980 RefSeq | MGI Sequence Detail 977 Not Specified  
    polypeptide P55050 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 67
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9705
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:7317 Alpers DH, et al., Cloning of a cDNA encoding rat intestinal fatty acid binding protein. Proc Natl Acad Sci U S A. 1984 Jan;81(2):313-7
    • Latest
      J:336753 Zinina VV, et al., TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine. Cells. 2023 May 23;12(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/19/2023
    MGI 6.22
    The Jackson Laboratory