Evx2 MGI Mouse Gene Detail - MGI:95462 - even-skipped homeobox 2

Symbol

Evx2
Name

even-skipped homeobox 2
Synonyms

Evx-2

Feature Type

protein coding gene
IDs

MGI:95462
NCBI Gene: 14029
Alliance

genome feature page
Transcription Start Sites

5 TSS
Regulated by

Rr566 (1 regulatory region)

Sequence Map

Chr2:74483335-74489901 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 44.13 cM
Mapping Data

7 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95462	protein coding gene	Chr2:74483333-74491864 (-)
129S1/SvImJ	ENSMUSG00200002854	protein coding gene	Chr2:71531975-71538541 (-)
A/J	ENSMUSG00195018843	protein coding gene	Chr2:71678683-71685248 (-)
AKR/J	ENSMUSG00220002281	protein coding gene	Chr2:71643318-71649883 (-)
BALB/cJ	ENSMUSG00180006752	protein coding gene	Chr2:71632349-71638914 (-)
C3H/HeJ	ENSMUSG00175010787	protein coding gene	Chr2:71758211-71764776 (-)
C57BL/6NJ	ENSMUSG00215020051	protein coding gene	Chr2:71595171-71601739 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023666	protein coding gene	Chr2:69457278-69463834 (-)
CAST/EiJ	ENSTCUG00005026990	protein coding gene	Chr2:71071934-71078483 (-)
CBA/J	ENSMUSG00210001900	protein coding gene	Chr2:71800854-71807419 (-)
DBA/2J	ENSMUSG00185011375	protein coding gene	Chr2:71636716-71643281 (-)
FVB/NJ	ENSMUSG00205011462	protein coding gene	Chr2:71088709-71095276 (-)
JF1/MsJ	ENSUMUG00000023578	protein coding gene	Chr2:71313689-71320231 (-)
LP/J	ENSMUSG00230023337	protein coding gene	Chr2:73431580-73438145 (-)
NOD/ShiLtJ	ENSMUSG00190010785	protein coding gene	Chr2:71711440-71718007 (-)
NZO/HlLtJ	ENSMUSG00225014172	protein coding gene	Chr2:81195640-81202206 (-)
PWK/PhJ	ENSLUMG00010029834	protein coding gene	Chr2:71552094-71558634 (-)
SPRET/EiJ	ENSMSPG00010018875	protein coding gene	Chr2:72952082-72958638 (-)
WSB/EiJ	ENSIUOG00005010908	protein coding gene	Chr2:71754726-71761289 (-)

Human Ortholog

EVX2, even-skipped homeobox 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EVX2, even-skipped homeobox 2
Synonyms

EVX-2
Links

HGNC:3507

NCBI Gene ID: 344191

UniProt: Q03828
Chr Location

2q31.1; chr2:176077472-176083962 (-) GRCh38

MGI Vertebrate Homology

Evx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EVX2
Gene Tree

Evx2

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Phenotype Summary

15 phenotypes from 3 alleles in 2 genetic backgrounds
12 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Radiation induced

1
Targeted

19
Genomic Mutations

12 involving Evx2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased body weight, male infertility, short limbs, and abnormalities in phalanx, carpal bone and metacarpal bone morphology.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

154
cDNA Data

15
Literature Summary

46

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase evx2

ZFIN evx2

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All Sequences

38
RefSeq

6
UniProt

3
CCDS

CCDS16138.1

Ensembl

ENSMUSG00000001815 (Evidence)
NCBI Gene

14029

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001815	Ensembl Gene Model \| MGI Sequence Detail	6567	C57BL/6J	± kb
transcript	ENSMUST00000173623	Ensembl \| MGI Sequence Detail	1428	Not Applicable
polypeptide	ENSMUSP00000134131	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007242 homeobox even-skipped homolog protein 2

(term hierarchy)
InterPro Domains

IPR052002 Even-skipped homeobox protein

IPR017970 Homeobox, conserved site

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily

IPR020479 Homeodomain, metazoa

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All nucleic 33

Genomic 10

cDNA 15

Primer pair 4

Other 4

Antibodies 1

Microarray probesets 3

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MGD-MRK-9675, MGD-MRK-9677

Summaries

All 102

Developmental Gene Expression 46

Gene Ontology 5

Phenotypes 32
Earliest

J:10491 Davisson MT, et al., The mouse mutation ulnaless on chromosome 2. J Hered. 1990 Mar-Apr;81(2):151-3
Latest

J:373797 Hintermann A, et al., Co-option of an ancestral cloacal regulatory landscape during digit evolution. Nature. 2025 Sep 17;

Evx2 expression regulated by:

Feature	Feature Type	Location	Reference
Rr566, regulatory region 566	enhancer	Chr2, Syntenic	J:83372

TSS for Evx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24621	Chr2:74491587-74491596 (-)	-1,691 bp
Tssr24620	Chr2:74491538-74491545 (-)	-1,641 bp
Tssr24619	Chr2:74490196-74490209 (-)	-302 bp
Tssr24618	Chr2:74490179-74490190 (-)	-284 bp
Tssr24617	Chr2:74490133-74490146 (-)	-239 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24