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Eif2b4 Gene Detail
Summary
  • Symbol
    Eif2b4
  • Name
    eukaryotic translation initiation factor 2B, subunit 4 delta
  • Synonyms
    Eif2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:95300
    NCBI Gene: 13667
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31344902-31350483 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.24 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95300
 protein coding gene Chr5:31344902-31350774 (-)
129S1/SvImJ ENSMUSG00200010435
 protein coding gene Chr5:26844657-26850536 (-)
A/J ENSMUSG00195047224
 protein coding gene Chr5:26291776-26297656 (-)
AKR/J ENSMUSG00220007138
 protein coding gene Chr5:26305862-26311741 (-)
BALB/cJ ENSMUSG00180034402
 protein coding gene Chr5:26096339-26102219 (-)
C3H/HeJ ENSMUSG00175038201
 protein coding gene Chr5:28070653-28076534 (-)
C57BL/6NJ ENSMUSG00215024234
 protein coding gene Chr5:26807994-26813867 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027083
 protein coding gene Chr5:25683728-25689304 (-)
CAST/EiJ ENSTCUG00005019143
 protein coding gene Chr5:26269423-26275341 (-)
CBA/J ENSMUSG00210038440
 protein coding gene Chr5:27043814-27049694 (-)
DBA/2J ENSMUSG00185034889
 protein coding gene Chr5:28899239-28905111 (-)
FVB/NJ ENSMUSG00205038595
 protein coding gene Chr5:25795253-25801134 (-)
JF1/MsJ ENSUMUG00000050975
 protein coding gene Chr5:33446607-33452546 (-)
LP/J ENSMUSG00230039126
 protein coding gene Chr5:33515074-33520953 (-)
NOD/ShiLtJ ENSMUSG00190012671
 protein coding gene Chr5:26096452-26102324 (-)
NZO/HlLtJ ENSMUSG00225018157
 protein coding gene Chr5:38723980-38729852 (-)
PWK/PhJ ENSLUMG00010041418
 protein coding gene Chr5:26187880-26193813 (-)
SPRET/EiJ ENSMSPG00010036736
 protein coding gene Chr5:27352258-27358074 (-)
WSB/EiJ ENSIUOG00005035194
 protein coding gene Chr5:28987652-28993531 (-)



Homology
more
  • Human Ortholog
    EIF2B4, eukaryotic translation initiation factor 2B subunit delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2B4, eukaryotic translation initiation factor 2B subunit delta
  • Synonyms
    EIF-2B, EIF2B, EIF2Bdelta, VWM4
  • Links
    NCBI Gene ID: 8890
    UniProt: Q9UI10

  • Chr Location
    2p23.3; chr2:27363420-27370400 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Eif2b4 mouse models; 1 with human EIF2B4 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a single point mutation exhibit decreased body weight, progressive ataxia, sporadic seizures, clinical features of vanishing cerebellum white matter, abnormal white matter astrocytes, retinal laminar disorganization, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    45
  • cDNA Data
    97
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13667 NCBI Gene Model | MGI Sequence Detail 5582 C57BL/6J ±  kb
    transcript NM_001127356 RefSeq | MGI Sequence Detail 2119 C57BL/6  
    polypeptide Q61749 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006965 translation initiation factor eIF2B subunit delta
      (term hierarchy)
    • InterPro Domains
      IPR042529 Initiation factor 2B-like, C-terminal
      IPR000649 Initiation factor 2B-related
      IPR027363 Methylthioribose-1-phosphate isomerase, N-terminal
      IPR037171 NagB/RpiA transferase-like
    • GlyGen
      Q61749 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9333
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:350737 Witkamp D, et al., Lithium: effects in animal models of vanishing white matter are not promising. Front Neurosci. 2024;18:1275744
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory