Eci1 MGI Mouse Gene Detail - MGI:94871 - enoyl-Coenzyme A delta isomerase 1

Symbol

Eci1
Name

enoyl-Coenzyme A delta isomerase 1
Synonyms

Dci, eci

Feature Type

protein coding gene
IDs

MGI:94871
NCBI Gene: 13177
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:24645657-24658290 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.39 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

485 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94871	protein coding gene	Chr17:24645615-24658322 (+)
129S1/SvImJ	ENSMUSG00200053817	protein coding gene	Chr17:20090542-20104792 (+)
A/J	ENSMUSG00195046909	protein coding gene	Chr17:21109370-21123621 (+)
AKR/J	ENSMUSG00220024707	protein coding gene	Chr17:20155713-20169989 (+)
BALB/cJ	ENSMUSG00180042970	protein coding gene	Chr17:20382940-20397197 (+)
C3H/HeJ	ENSMUSG00175047342	protein coding gene	Chr17:20141356-20155595 (+)
C57BL/6NJ	ENSMUSG00215052487	protein coding gene	Chr17:20153586-20166294 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021183	protein coding gene	Chr17:20245906-20261192 (+)
CAST/EiJ	ENSTCUG00005049079	protein coding gene	Chr17:20723407-20736258 (+)
CBA/J	ENSMUSG00210032946	protein coding gene	Chr17:19980187-19994426 (+)
DBA/2J	ENSMUSG00185049982	protein coding gene	Chr17:22197706-22211956 (+)
FVB/NJ	ENSMUSG00205049797	protein coding gene	Chr17:20449281-20463560 (+)
JF1/MsJ	ENSUMUG00000056901	protein coding gene	Chr17:21645401-21658108 (+)
LP/J	ENSMUSG00230054984	protein coding gene	Chr17:23595087-23609655 (+)
NOD/ShiLtJ	ENSMUSG00190032937	protein coding gene	Chr17:20086456-20100706 (+)
NZO/HlLtJ	ENSMUSG00225049866	protein coding gene	Chr17:25516724-25531291 (+)
PWK/PhJ	ENSLUMG00010017136	protein coding gene	Chr17:19556121-19568799 (+)
SPRET/EiJ	ENSMSPG00010044723	protein coding gene	Chr17:20889738-20903653 (+)
WSB/EiJ	ENSIUOG00005050596	protein coding gene	Chr17:20835481-20849729 (+)

Human Ortholog

ECI1, enoyl-CoA delta isomerase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ECI1, enoyl-CoA delta isomerase 1
Synonyms

DCI
Links

HGNC:2703

NCBI Gene ID: 1632

UniProt: P42126
Chr Location

16p13.3; chr16:2239402-2252300 (-) GRCh38

MGI Vertebrate Homology

Eci1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ECI1
Gene Tree

Eci1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

5
Gene trapped

9
Targeted

1
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene are normal until stressed. Starvation results in increased accumulation of triglycerides and unsaturated fatty acids in the liver and kidney. Secretion of fatty acid metabolites in the urine is greatly increased.

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All GO Annotations

23
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

695
Tissues

97
cDNA Data

83
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ECI1

Xenbase eci1

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All Sequences

52
RefSeq

2
UniProt

5
CCDS

CCDS28480.1

Ensembl

ENSMUSG00000024132 (Evidence)
NCBI Gene

13177

			Length	Strain/Species	Flank
genomic	13177	NCBI Gene Model \| MGI Sequence Detail	12634	C57BL/6J	± kb
transcript	NM_010023	RefSeq \| MGI Sequence Detail	1091	Not Specified
polypeptide	P42125	UniProt \| EBI \| MGI Sequence Detail	289	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006308 enoyl-CoA Delta isomerase 1, mitochondrial

(term hierarchy)
EC

5.3.3.8
InterPro Domains

IPR029045 ClpP/crotonase-like domain superfamily

IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

IPR001753 Enoyl-CoA hydratase/isomerase-like domain
GlyGen

P42125 1 site, 1 O-linked glycan (1 site)

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All nucleic 89

Genomic 2

cDNA 84

Primer pair 3

Microarray probesets 3

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MGD-MRK-8810

Summaries

All 51

Developmental Gene Expression 4

Gene Ontology 15

Phenotypes 9
Earliest

J:15191 Stoffel W, et al., Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase. FEBS Lett. 1993 Oct 25;333(1-2):119-22
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Eci1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143030	Chr17:24644465-24644500 (+)	-1,174 bp
Tssr143031	Chr17:24645650-24645675 (+)	6 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24