Serping1 MGI Mouse Gene Detail - MGI:894696 - serine (or cysteine) peptidase inhibitor, clade G, member 1

Symbol

Serping1
Name

serine (or cysteine) peptidase inhibitor, clade G, member 1
Synonyms

C1INH, C1 inhibitor, C1nh

Feature Type

protein coding gene
IDs

MGI:894696
NCBI Gene: 12258
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:84595731-84605788 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

4 experiments

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894696	protein coding gene	Chr2:84595704-84605788 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025910	protein coding gene	Chr2:85455494-85465401 (-)
A/J	MGP_AJ_G0025884	protein coding gene	Chr2:82151028-82160877 (-)
AKR/J	MGP_AKRJ_G0025854	protein coding gene	Chr2:84268351-84280032 (-)
BALB/cJ	MGP_BALBcJ_G0025881	protein coding gene	Chr2:82284257-82294274 (-)
C3H/HeJ	MGP_C3HHeJ_G0025640	protein coding gene	Chr2:84511582-84523404 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026327	protein coding gene	Chr2:88103439-88114381 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023729	protein coding gene	Chr2:78976910-78986912 (-)
CAST/EiJ	MGP_CASTEiJ_G0025101	protein coding gene	Chr2:85041066-85052585 (-)
CBA/J	MGP_CBAJ_G0025621	protein coding gene	Chr2:91254185-91266535 (-)
DBA/2J	MGP_DBA2J_G0025752	protein coding gene	Chr2:81689507-81699376 (-)
FVB/NJ	MGP_FVBNJ_G0025715	protein coding gene	Chr2:80945646-80956754 (-)
LP/J	MGP_LPJ_G0025840	protein coding gene	Chr2:85253508-85265172 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025745	protein coding gene	Chr2:93574759-93586353 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026383	protein coding gene	Chr2:84505673-84521639 (-)
PWK/PhJ	MGP_PWKPhJ_G0024845	protein coding gene	Chr2:81531251-81541611 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024649	protein coding gene	Chr2:84644646-84654496 (-)
WSB/EiJ	MGP_WSBEiJ_G0025171	protein coding gene	Chr2:85173216-85183949 (-)

Human Ortholog

SERPING1, serpin family G member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPING1, serpin family G member 1
Synonyms

C1IN, C1INH, C1NH, HAE1, HAE2
Links

HGNC:1228

NCBI Gene ID: 710

neXtProt AC: NX_P05155

UniProt: P05155
Chr Location

11q12.1; chr11:57597387-57619171 (+) GRCh38

Alliance of Genome Resources

Serping1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SERPING1
Gene Tree

Serping1

Diseases

8 with human SERPING1 associations

				Human Disease	Mouse Models
				angioedema IDs angioedema DOID:1558 ICD10CM:T78.3 MESH:D000799 NCI:C112175 UMLS_CUI:C0002994
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				hereditary angioedema IDs hereditary angioedema DOID:14735 MESH:D054179 NCI:C84758 UMLS_CUI:C0019243
				hereditary angioedema type I IDs hereditary angioedema type I DOID:0080939 OMIM:106100
				macular degeneration IDs macular degeneration DOID:4448 MESH:D008268 NCI:C123330 ORDO:279 UMLS_CUI:C0024437
				pancreatitis IDs pancreatitis DOID:4989 EFO:0000278 ICD10CM:K85.9 MESH:D010195 NCI:C3306 OMIM:167800 UMLS_CUI:C0030305
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

27
Gene trapped

6
Targeted

6
Genomic Mutations

3 involving Serping1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutant mice exhibit an increased vascular permeability compared to controls.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

20
cDNA Data

254
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN serping1

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Serping1 interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS16193.1

Ensembl

ENSMUSG00000023224 (Evidence)
NCBI Gene

12258

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023224	Ensembl Gene Model \| MGI Sequence Detail	10058	C57BL/6J	± kb
transcript	ENSMUST00000023994	Ensembl \| MGI Sequence Detail	1768	Not Applicable
polypeptide	ENSMUSP00000023994	Ensembl \| MGI Sequence Detail	504	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014707 plasma protease C1 inhibitor

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 258

Genomic 2

cDNA 254

Primer pair 2

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 20
Earliest

J:40775 Russell JA, et al., The sequence of a cDNA encoding functional murine C1-inhibitor protein. Biochim Biophys Acta. 1997 May 30;1352(2):156-60
Latest

J:342527 Bupp S, et al., A novel murine in vivo model for acute hereditary angioedema attacks. Sci Rep. 2021 Aug 5;11(1):15924

TSS for Serping1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25053	Chr2:84605764-84605782 (-)	15 bp
Tssr25052	Chr2:84605732-84605755 (-)	44 bp
Tssr25051	Chr2:84605207-84605220 (-)	574 bp
Tssr25050	Chr2:84605153-84605204 (-)	609 bp
Tssr25049	Chr2:84605140-84605151 (-)	642 bp
Tssr25048	Chr2:84603981-84603993 (-)	1,801 bp
Tssr25047	Chr2:84603858-84603897 (-)	1,910 bp
Tssr25046	Chr2:84603772-84603808 (-)	1,998 bp
Tssr25045	Chr2:84603716-84603749 (-)	2,055 bp
Tssr25044	Chr2:84603682-84603715 (-)	2,089 bp
Tssr25043	Chr2:84603601-84603611 (-)	2,182 bp
Tssr25042	Chr2:84603585-84603596 (-)	2,197 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22