Serpinb6b Gene Detail

Summary

• Symbol
  Serpinb6b
• Name
  serine (or cysteine) peptidase inhibitor, clade B, member 6b
• Synonyms
  NK13, ovalbumin, Spi12

• Feature Type
  protein coding gene
• IDs
  MGI:894688
  NCBI Gene: 20708
• Alliance
  genome feature page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr13:33149192-33163050 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 13.78 cM, cytoband A4
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  355 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894688	protein coding gene	Chr13:33140797-33163050 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020430	protein coding gene	Chr13:30969948-30983806 (+)
A/J	MGP_AJ_G0020385	protein coding gene	Chr13:30118441-30132299 (+)
AKR/J	MGP_AKRJ_G0020362	protein coding gene	Chr13:30780947-30794805 (+)
BALB/cJ	MGP_BALBcJ_G0020380	protein coding gene	Chr13:30200950-30214808 (+)
C3H/HeJ	MGP_C3HHeJ_G0020183	protein coding gene	Chr13:30771062-30784920 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020816	protein coding gene	Chr13:31994561-32008419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018407	protein coding gene	Chr13:28436010-28452193 (+)
CAST/EiJ	MGP_CASTEiJ_G0019700	protein coding gene	Chr13:30492394-30506242 (+)
CBA/J	MGP_CBAJ_G0020139	protein coding gene	Chr13:33400079-33413937 (+)
DBA/2J	MGP_DBA2J_G0020261	protein coding gene	Chr13:29627744-29641602 (+)
FVB/NJ	MGP_FVBNJ_G0020246	protein coding gene	Chr13:29251696-29265554 (+)
LP/J	MGP_LPJ_G0020338	protein coding gene	Chr13:31187681-31201539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020272	protein coding gene	Chr13:33484522-33498380 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020857	protein coding gene	Chr13:30455386-30469244 (+)
PWK/PhJ	MGP_PWKPhJ_G0019455	protein coding gene	Chr13:29820101-29835502 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019276	protein coding gene	Chr13:29369967-29385048 (+)
WSB/EiJ	MGP_WSBEiJ_G0019762	protein coding gene	Chr13:30769742-30783592 (+)

Homology

• Human Ortholog
  SERPINB6, serpin family B member 6

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SERPINB6, serpin family B member 6
  
• Synonyms
  CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
• Links
  HGNC:8950

  NCBI Gene ID: 5269

  UniProt: P35237

  
  
• Chr Location
  6p25.2; chr6:2948158-2972375 (-)  GRCh38

---

• MGI Vertebrate Homology
  Serpinb6b stringent orthology
  1 human;1 mouse;1 rat;4 zebrafish
  
• HCOP
  vertebrate homology predictions: SERPINB6
• Gene Tree
  Serpinb6b
  

Human Diseases

• Diseases
  1 with human SERPINB6 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 91 IDs autosomal recessive nonsyndromic deafness 91       DOID:0110536 ICD10CM:H90.3 OMIM:613453

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Serpinb6b
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  34 strains or lines available

Expression

• Assay Results
  811
• Tissues
  23
• cDNA Data
  40
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  6
• UniProt
  5
• CCDS
  CCDS26430.1

• Ensembl
  ENSMUSG00000042842 (Evidence)
• NCBI Gene
  20708

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000042842	Ensembl Gene Model | MGI Sequence Detail	13859	C57BL/6J
transcript	ENSMUST00000110293	Ensembl | MGI Sequence Detail	2193	Not Applicable
polypeptide	ENSMUSP00000105922	Ensembl | MGI Sequence Detail	377	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR023795 Serpin, conserved site
  IPR023796 Serpin domain
  IPR000215 Serpin family
  IPR036186 Serpin superfamily
  IPR042178 Serpin superfamily, domain 1
  IPR042185 Serpin superfamily, domain 2

Molecular
Reagents

• All nucleic 46

  Genomic 2

  cDNA 40

  Primer pair 3

  Other 1

  
  

  Microarray probesets 4

References

• Summaries
  All 34

  Developmental Gene Expression 3

  Phenotypes 11
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:305733 Yu HF, et al., Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization. J Cell Mol Med. 2020 Jun;24(12):7023-7033

TSS for Serpinb6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119155	Chr13:33149237-33149250 (+)	52 bp
Tssr119156	Chr13:33149255-33149266 (+)	69 bp
Tssr119157	Chr13:33149286-33149300 (+)	101 bp
Tssr119158	Chr13:33149306-33149313 (+)	118 bp
Tssr119159	Chr13:33149477-33149494 (+)	294 bp
Tssr119160	Chr13:33149676-33149695 (+)	494 bp