Serpinb6b MGI Mouse Gene Detail - MGI:894688 - serine (or cysteine) peptidase inhibitor, clade B, member 6b

Symbol

Serpinb6b
Name

serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms

NK13, ovalbumin, Spi12

Feature Type

protein coding gene
IDs

MGI:894688
NCBI Gene: 20708
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:33149192-33163050 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.78 cM, cytoband A4
Mapping Data

4 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894688	protein coding gene	Chr13:33140797-33163050 (+)
129S1/SvImJ	ENSMUSG00200028106	protein coding gene	Chr13:30343811-30357669 (+)
A/J	ENSMUSG00195036952	protein coding gene	Chr13:29441446-29455305 (+)
AKR/J	ENSMUSG00220012252	protein coding gene	Chr13:29300792-29314650 (+)
BALB/cJ	ENSMUSG00180022271	protein coding gene	Chr13:29741611-29755469 (+)
C3H/HeJ	ENSMUSG00175030174	protein coding gene	Chr13:29763832-29777690 (+)
C57BL/6NJ	ENSMUSG00215008193	protein coding gene	Chr13:29941949-29955807 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018407	protein coding gene	Chr13:28436010-28452193 (+)
CAST/EiJ	ENSTCUG00005009499	protein coding gene	Chr13:29896813-29910661 (+)
CBA/J	ENSMUSG00210026530	protein coding gene	Chr13:29707419-29721277 (+)
DBA/2J	ENSMUSG00185031039	protein coding gene	Chr13:30526503-30540361 (+)
FVB/NJ	ENSMUSG00205022353	protein coding gene	Chr13:29560320-29574176 (+)
JF1/MsJ	ENSUMUG00000012024	protein coding gene	Chr13:30176878-30191879 (+)
LP/J	ENSMUSG00230017972	protein coding gene	Chr13:39851056-39864914 (+)
NOD/ShiLtJ	ENSMUSG00190029153	protein coding gene	Chr13:29924414-29938272 (+)
NZO/HlLtJ	ENSMUSG00225033697	protein coding gene	Chr13:33658526-33672384 (+)
PWK/PhJ	ENSLUMG00010028120	protein coding gene	Chr13:28975019-28990078 (+)
SPRET/EiJ	ENSMSPG00010022852	protein coding gene	Chr13:29089177-29107457 (+)
WSB/EiJ	ENSIUOG00005016118	protein coding gene	Chr13:29114916-29128766 (+)

Human Ortholog

SERPINB6, serpin family B member 6

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB6, serpin family B member 6
Synonyms

CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Links

HGNC:8950

NCBI Gene ID: 5269

UniProt: P35237
Chr Location

6p25.2; chr6:2948158-2972375 (-) GRCh38

MGI Vertebrate Homology

Serpinb6b stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: SERPINB6
Gene Tree

Serpinb6b

Diseases

1 with human SERPINB6 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 91 IDs autosomal recessive nonsyndromic deafness 91 DOID:0110536 ICD10CM:H90.3 OMIM:613453

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Serpinb6b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

702
Tissues

23
cDNA Data

40
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS26430.1

Ensembl

ENSMUSG00000042842 (Evidence)
NCBI Gene

20708

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042842	Ensembl Gene Model \| MGI Sequence Detail	13859	C57BL/6J	± kb
transcript	ENSMUST00000110293	Ensembl \| MGI Sequence Detail	2193	Not Applicable
polypeptide	ENSMUSP00000105922	Ensembl \| MGI Sequence Detail	377	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 46

Genomic 2

cDNA 40

Primer pair 3

Other 1

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:316702 Garzon-Tituana M, et al., Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. Theranostics. 2021;11(8):3781-3795

TSS for Serpinb6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119155	Chr13:33149237-33149250 (+)	52 bp
Tssr119156	Chr13:33149255-33149266 (+)	69 bp
Tssr119157	Chr13:33149286-33149300 (+)	101 bp
Tssr119158	Chr13:33149306-33149313 (+)	118 bp
Tssr119159	Chr13:33149477-33149494 (+)	294 bp
Tssr119160	Chr13:33149676-33149695 (+)	494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24