Prdx6 MGI Mouse Gene Detail - MGI:894320

Symbol

Prdx6
Name

peroxiredoxin 6
Synonyms

1-cysPrx, 1-Cys Prx, 9430088D19Rik, acidic calcium-independent phospholipase A2, aiPLA2, Aop2, Brp-12, CC26, CP-3, GPx, Ltw4, Ltw-4, Lvtw-4, NSGP

Feature Type

protein coding gene
IDs

MGI:894320
NCBI Gene: 11758
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:161067682-161078780 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.75 cM
Mapping Data

33 experiments

SNPs within 2kb

126 from dbSNP Build 142
Strain Annotations

18
PCR

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894320	protein coding gene	Chr1:161067682-161078789 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016651	protein coding gene	Chr1:166502906-166532802 (-)
A/J	MGP_AJ_G0016632	protein coding gene	Chr1:159725692-159736799 (-)
AKR/J	MGP_AKRJ_G0016598	protein coding gene	Chr1:164594241-164605348 (-)
BALB/cJ	MGP_BALBcJ_G0016593	protein coding gene	Chr1:160276354-160287482 (-)
C3H/HeJ	MGP_C3HHeJ_G0016417	protein coding gene	Chr1:164812074-164823211 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017054	protein coding gene	Chr1:172154466-172165568 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014763	protein coding gene	Chr1:151845942-151857326 (-)
CAST/EiJ	MGP_CASTEiJ_G0015997	protein coding gene	Chr1:164419210-164430310 (-)
CBA/J	MGP_CBAJ_G0016392	protein coding gene	Chr1:178248665-178259811 (-)
DBA/2J	MGP_DBA2J_G0016498	protein coding gene	Chr1:158706486-158718066 (-)
FVB/NJ	MGP_FVBNJ_G0016496	protein coding gene	Chr1:157112166-157123273 (-)
LP/J	MGP_LPJ_G0016569	protein coding gene	Chr1:167594779-167609337 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016521	protein coding gene	Chr1:185806135-185817242 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017090	protein coding gene	Chr1:164420919-164432022 (-)
PWK/PhJ	MGP_PWKPhJ_G0015783	protein coding gene	Chr1:157865179-157876300 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015570	protein coding gene	Chr1:163318056-163329162 (-)
WSB/EiJ	MGP_WSBEiJ_G0016059	protein coding gene	Chr1:164604861-164615990 (-)

Human Ortholog

PRDX6, peroxiredoxin 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRDX6, peroxiredoxin 6
Synonyms

1-Cys, aiPLA2, AOP2, HEL-S-128m, LPCAT-5, NSGPx, p29, PRX
Links

HGNC:16753

NCBI Gene ID: 9588

neXtProt AC: NX_P30041

UniProt: P30041
Chr Location

1q25.1; chr1:173477347-173488807 (+) GRCh38.p7

Alliance of Genome Resources

Prdx6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRDX6
Protein SuperFamily

AHPC
Gene Tree

Prdx6

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Phenotype Summary

28 phenotypes from 5 alleles in 5 genetic backgrounds
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

38
Targeted

11
Transgenic

1
Genomic Mutations

2 involving Prdx6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions of this gene show no macroscopic or microscopic abnormalities. However, they have an increased susceptibility to oxidative stress.

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All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1016
Tissues

145
cDNA Data

397
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PRDX6

Xenbase prdx6

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Prdx6 interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

78
RefSeq

7
UniProt

7
CCDS

CCDS15415.1, CCDS78724.1

Ensembl

ENSMUSG00000026701 (Evidence)
NCBI Gene

11758

			Length	Strain/Species	Flank
genomic	11758	NCBI Gene Model \| MGI Sequence Detail	11099	C57BL/6J	± kb
transcript	NM_001303408	RefSeq \| MGI Sequence Detail	2489	C57BL/6
polypeptide	O08709	UniProt \| EBI \| MGI Sequence Detail	224	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013196 peroxiredoxin-6

(term hierarchy)
EC

1.11.1.27, 2.3.1.23, 3.1.1.4
InterPro Domains

IPR045020 1-Cys peroxiredoxin

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

IPR024706 Peroxiredoxin, AhpC-type

IPR019479 Peroxiredoxin, C-terminal

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily

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All nucleic 404

Genomic 4

cDNA 397

Primer pair 3

Microarray probesets 4

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MGD-MRK-11921, MGD-MRK-11926, MGD-MRK-11944, MGD-MRK-1637, MGI:2444784, MGI:3035058, MGI:96849

Summaries

All 148

Developmental Gene Expression 13

Gene Ontology 10

Phenotypes 67
Earliest

J:6130 Elliott RW, Use of two-dimensional electrophoresis to identify and map new mouse genes. Genetics. 1979 Feb;91(2):295-308
Latest

J:332076 Paluchova V, et al., The role of peroxiredoxin 6 in biosynthesis of FAHFAs. Free Radic Biol Med. 2022 Nov 20;193(Pt 2):787-794

TSS for Prdx6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14581	Chr1:161079072-161079098 (-)	-305 bp
Tssr14580	Chr1:161078723-161078756 (-)	40 bp
Tssr14579	Chr1:161078711-161078714 (-)	67 bp
Tssr14578	Chr1:161078698-161078709 (-)	76 bp
Tssr14577	Chr1:161078454-161078479 (-)	313 bp
Tssr14576	Chr1:161071182-161071211 (-)	7,583 bp
Tssr14575	Chr1:161069339-161069361 (-)	9,430 bp
Tssr14574	Chr1:161069231-161069250 (-)	9,539 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22