Mal MGI Mouse Gene Detail - MGI:892970 - myelin and lymphocyte protein, T cell differentiation protein

Symbol

Mal
Name

myelin and lymphocyte protein, T cell differentiation protein
Synonyms

VIP17

Feature Type

protein coding gene
IDs

MGI:892970
NCBI Gene: 17153
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:127475146-127498615 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.06 cM
Mapping Data

2 experiments

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_892970	protein coding gene	Chr2:127475146-127498615 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026465	protein coding gene	Chr2:130925828-130949221 (-)
A/J	MGP_AJ_G0026429	protein coding gene	Chr2:125624212-125647821 (-)
AKR/J	MGP_AKRJ_G0026404	protein coding gene	Chr2:129208292-129231527 (-)
BALB/cJ	MGP_BALBcJ_G0026441	protein coding gene	Chr2:125890817-125914732 (-)
C3H/HeJ	MGP_C3HHeJ_G0026184	protein coding gene	Chr2:129722650-129746078 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026886	protein coding gene	Chr2:135030924-135055646 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024263	protein coding gene	Chr2:120468333-120492475 (-)
CAST/EiJ	MGP_CASTEiJ_G0025645	protein coding gene	Chr2:129923557-129946987 (-)
CBA/J	MGP_CBAJ_G0026164	protein coding gene	Chr2:140033064-140056521 (-)
DBA/2J	MGP_DBA2J_G0026298	protein coding gene	Chr2:125030482-125053913 (-)
FVB/NJ	MGP_FVBNJ_G0026262	protein coding gene	Chr2:123683461-123707326 (-)
LP/J	MGP_LPJ_G0026403	protein coding gene	Chr2:131171227-131197377 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026282	protein coding gene	Chr2:144046255-144070722 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026941	protein coding gene	Chr2:129231149-129257286 (-)
PWK/PhJ	MGP_PWKPhJ_G0025381	protein coding gene	Chr2:124579700-124603953 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025183	protein coding gene	Chr2:128312992-128338086 (-)
WSB/EiJ	MGP_WSBEiJ_G0025719	protein coding gene	Chr2:130136971-130161315 (-)

Human Ortholog

MAL, mal, T cell differentiation protein

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAL, mal, T cell differentiation protein
Synonyms

MVP17, VIP17
Links

HGNC:6817

NCBI Gene ID: 4118

neXtProt AC: NX_P21145

UniProt: P21145
Chr Location

2q11.1; chr2:95025677-95053992 (+) GRCh38

MGI Vertebrate Homology

Mal stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: MAL
Gene Tree

Mal

Diseases

1 with human MAL associations

				Human Disease	Mouse Models
				metachromatic leukodystrophy IDs metachromatic leukodystrophy DOID:10581 ICD10CM:E75.25 MESH:D007966 NCI:C61251 OMIM:249900 OMIM:250100 ORDO:512 UMLS_CUI:C0023522

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Transgenic

1
Genomic Mutations

2 involving Mal
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal myelination and optic nerve morphology.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

786
Tissues

37
cDNA Data

37
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mal

ZFIN malb

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS16707.1, CCDS50705.1

Ensembl

ENSMUSG00000027375 (Evidence)
NCBI Gene

17153

			Length	Strain/Species	Flank
genomic	17153	NCBI Gene Model \| MGI Sequence Detail	23470	C57BL/6J	± kb
transcript	NM_010762	RefSeq \| MGI Sequence Detail	2792	C57BL/6
polypeptide	O09198	UniProt \| EBI \| MGI Sequence Detail	153	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010092 myelin and lymphocyte protein

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR013295 Myelin and lymphocyte (MAL) protein

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All nucleic 41

Genomic 4

cDNA 37

Microarray probesets 4

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:324531 Kim H, et al., Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression. Elife. 2022 May 10;11:e72290

TSS for Mal:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26136	Chr2:127498165-127498176 (-)	444 bp
Tssr26135	Chr2:127498129-127498152 (-)	474 bp
Tssr26134	Chr2:127498102-127498116 (-)	506 bp
Tssr26133	Chr2:127498077-127498086 (-)	533 bp
Tssr26132	Chr2:127475520-127475537 (-)	23,086 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23